Associations of cardiovascular risk with circulating peptides related to hypertensive disorders of pregnancy
Associations of cardiovascular risk with circulating peptides related to hypertensive disorders of pregnancy
复制标题
DOI：
10.1038/s41440-021-00747-6
复制
发表时间：
2021-09-28
影响因子：
5.4
通讯作者：
Araki, Yoshihiko
中科院分区：
文献类型：
--
作者：
Wakabayashi, Ichiro;Yanagida, Mitsuaki;Araki, Yoshihiko
我们之前在血清中发现了7种与妊娠期高血压疾病（HDP）相关的肽。然而，这些肽在一般人群中的意义尚不清楚。本研究的目的是阐明成年男性高血压和其他心血管风险与hdp相关肽的关系。我们调查了在工作场所每年接受健康检查的男性（平均年龄：46.4岁）中肽水平与心血管危险因素的关系，包括肥胖、血压、血脂和血糖状态。用质谱仪同时测定血清中上述7种多肽的浓度。7种多肽中，只有纤维蛋白原- α衍生的m/z 2091 （P-2091）多肽与舒张压有显著相关性（Spearman等级相关系数[r]， -0.446）。另一种来自补体成分4的含有m/z 2378的肽（P-2378）与体重指数呈显著正相关（r, 0.273），与高密度脂蛋白胆固醇呈显著负相关（r, -0.336）。此外，从α -胰蛋白酶抑制剂中提取的含有m/z 3156 （P-3156）的肽与体重指数（r, -0.258）和甘油三酯（r, -0.334）呈显著负相关。这7种多肽的水平与糖化血红蛋白之间没有明显的相关性。在与HDP相关的7个多肽中，P-2091、P-2378和P-3156分别与舒张压、HDL胆固醇和甘油三酯呈负相关。因此，这些肽可能是区分普通人群心血管风险的生物标志物。
We previously identified seven peptides in serum that are associated with hypertensive disorders of pregnancy (HDP). However, the significance of these peptides in the general population is unknown. The aim of this study was to clarify the relationships of HDP-associated peptides with hypertension and other cardiovascular risks in adult men. We investigated the relationships of peptide levels with cardiovascular risk factors, including adiposity, blood pressure, blood lipids and glycemic status, in men (mean age: 46.4 years) who were receiving annual health checkups at their workplace. The concentrations of the abovementioned seven peptides in serum were measured simultaneously using a mass spectrometer. Among the seven peptides, only a peptide with m/z 2091 (P-2091) derived from fibrinogen-alpha showed a significant correlation with diastolic blood pressure (Spearman's rank correlation coefficient [r], -0.446). Another peptide with m/z 2378 (P-2378) originating from complement component 4 showed a significant positive correlation with body mass index (r, 0.273) and a significant inverse correlation with HDL cholesterol (r, -0.336). In addition, a peptide with m/z 3156 (P-3156) derived from an inter-alpha-trypsin inhibitor showed significant inverse correlations with body mass index (r, -0.258) and triglycerides (r, -0.334). There was no significant correlation of the levels of any of the seven peptides with hemoglobin A1c. Among the seven peptides related to HDP, P-2091, P-2378 and P-3156 were inversely associated with diastolic blood pressure, HDL cholesterol and triglycerides, respectively. Therefore, these peptides are possible biomarkers for discriminating cardiovascular risk in a general population.