Ca(2+) influx at the ER/PM junctions.
Ca(2+) influx at the ER/PM junctions.
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DOI：
10.1016/j.ceca.2017.02.009
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发表时间：
2017-05
期刊：
影响因子：
4
通讯作者：
Muallem S
中科院分区：
文献类型：
--
作者：
Chung WY;Jha A;Ahuja M;Muallem S
Ca2+内流穿过质膜是受体诱发的Ca2+信号的关键组成部分，介导许多细胞功能，并在部分或全部ER Ca2+储存耗尽后重新加载内质网。Ca2+内流是在响应内质网Ca2+释放时被激活的，这是Jim Putney提出的一个概念，介导内流的通道因此被称为储存操作的Ca2+内流通道，或soc。通过鉴定TRPC通道、STIM1通道和Orai通道，确定了SOCs的分子特性。这些通道在ER/PM连接处被靶向、运作和调节。内质网/PM连接是存在于细胞所有部分的膜接触位点（MCSs）的一种形式，内质网在其中与细胞膜和细胞器接触。MCSs具有多种细胞功能，是脂质和Ca2+在细胞器之间运输和递送的场所。这篇简短的综述讨论了MCSs在脂质和Ca2+运输背景下的各个方面。
Ca2+ influx across the plasma membrane is a key component of the receptor-evoked Ca2+ signaling that mediate numerous cell functions and reload the ER after partial or full ER Ca2+ store depletion. Ca2+ influx is activated in response to Ca2+ release from the ER, a concept developed by Jim Putney, and the channels mediating the influx are thus called store-operated Ca2+ influx channels, or SOCs. The molecular identity of the SOCs has been determined with the identification of the TRPC channels, STIM1 and the Orai channels. These channels are targeted to, operate and are regulated when at the ER/PM junctions. ER/PM junctions are a form of membrane contact sites (MCSs) that are present in all parts of the cells, where the ER makes contacts with cellular membranes and organelles. MCSs have many cellular functions, and are the sites of lipid and Ca2+ transport and delivery between organelles. This short review discusses aspects of MCSs in the context of lipid and Ca2+ transport.