Assessing the State of Chronic Spinal Cord Injury Using Diffusion Tensor Imaging
Assessing the State of Chronic Spinal Cord Injury Using Diffusion Tensor Imaging
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DOI：
10.1089/neu.2013.2943
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发表时间：
2013-09-15
影响因子：
4.2
通讯作者：
Ohman, Juha
中科院分区：
文献类型：
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作者：
Koskinen, Eerika;Brander, Antti;Ohman, Juha
本研究的目的是量化慢性创伤性脊髓损伤 (SCI) 患者颈髓弥散张量成像 (DTI) 参数与神经功能障碍之间的关联。对 28 名慢性创伤性 SCI 患者和 40 名健康对照受试者进行了颈髓 3T 磁共振成像 (MRI) 和 DTI 序列。 DTI 指标，包括分数各向异性 (FA)、表观扩散系数 (ADC)、轴向扩散率 (AD) 和径向扩散率 (RD)，是在 C2 或 C3 水平的正常脊髓区域内计算的。根据脊髓损伤神经学分类国际标准 (ISNCSCI) 和功能独立测量 (FIM) 的运动分量表对患者进行临床评估。 SCI患者的FA值显着低于健康对照者（p
The aim of this study was to quantify the association between diffusion tensor imaging (DTI) parameters of the cervical spinal cord and neurological disability in patients with chronic traumatic spinal cord injury (SCI). A cervical spinal cord 3T magnetic resonance imaging (MRI) with DTI sequences was performed on 28 patients with chronic traumatic SCI and 40 healthy control subjects. DTI metrics, including fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusivity (AD), and radial diffusivity (RD), were calculated within the normal-appearing spinal cord area at levels C2 or C3. Clinical assessment of the patients was performed according to the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) and the motor subscale of the Functional Independence Measure (FIM). The FA values of the patients with SCI were significantly lower than those of healthy control subjects (p