Functional specialization of presynaptic Cav2.3 Ca2+ channels
Functional specialization of presynaptic Cav2.3 Ca2+ channels
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DOI：
10.1016/s0896-6273(03)00430-6
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发表时间：
2003-07-31
期刊：
影响因子：
16.2
通讯作者：
Beck, H
中科院分区：
文献类型：
--
作者：
Dietrich, D;Kirschstein, T;Beck, H
Ca2+通过电压依赖性Call通道流入突触前末梢，触发快速神经递质释放以及不同形式的突触可塑性。使用电生理和遗传技术，我们证明，突触前呼叫进入通过Ca（v）2.3亚基有助于诱导苔藓纤维LTP和强直后增强的短暂列车突触前动作电位，而他们不发挥作用，在快速突触传递，成对脉冲促进，或频率促进。这种功能的专业化是最有可能实现的本地化远程释放机械和Cav2.3通道依赖性促进突触前呼叫涌入。因此，Ca（v）2.3通道的存在促进了突触前Ca 2+的积累，触发突触前LTP和强直后增强，而不影响低释放概率，这是苔藓纤维突触显示的巨大可塑性的先决条件。
Ca2+ influx into presynaptic terminals via voltage-dependent Call channels triggers fast neurotransmitter release as well as different forms of synaptic plasticity. Using electrophysiological and genetic techniques we demonstrate that presynaptic Call entry through Ca(v)2.3 subunits contributes to the induction of mossy fiber LTP and posttetanic potentiation by brief trains of presynaptic action potentials while they do not play a role in fast synaptic transmission, paired-pulse facilitation, or frequency facilitation. This functional specialization is most likely achieved by a localization remote from the release machinery and by a Cav2.3 channel-dependent facilitation of presynaptic Call influx. Thus, the presence of Ca(v)2.3 channels boosts the accumulation of presynaptic Ca2+ triggering presynaptic LTP and posttetanic potentiation without affecting the low release probability that is a prerequisite for the enormous plasticity displayed by mossy fiber synapses.