β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease.
β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease.
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DOI：
10.1371/journal.pone.0134742
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Pereira LJ
中科院分区：
文献类型：
--
作者：
Silva Vde O;Lobato RV;Andrade EF;de Macedo CG;Napimoga JT;Napimoga MH;Messora MR;Murata RM;Pereira LJ
本研究的目的是评估口服从酵母中分离的β-葡聚糖对牙周病糖尿病大鼠代谢谱、牙龈炎症标志物表达和牙槽骨丢失量的影响。以48只Wistar大鼠为实验对象，腹腔注射链脲佐菌素（80 mg/kg）诱导糖尿病。确诊糖尿病后，给予β-葡聚糖（灌胃）治疗28 d。在这段时间的第14天，采用结扎法诱导牙周病。β-葡聚糖降低了糖尿病组和非糖尿病组牙周病动物的牙槽骨丢失量（p < 0.05）。β-葡聚糖降低了糖尿病动物的血糖、胆固醇和三酰甘油水平，无论有无牙周病（p < 0.05）。此外，β-葡聚糖降低了糖尿病和牙周病动物环氧化酶-2和核因子κ b配体受体激活剂的表达，增加了骨保护素的表达（p < 0.05）。由此可见，β-葡聚糖对糖尿病大鼠牙周病有有益的代谢和牙周作用。
The objective of this study was to assess the effects of oral ingestion of β-glucans isolated from Saccharomyces cereviseae on the metabolic profile, expression of gingival inflammatory markers and amount of alveolar bone loss in diabetic rats with periodontal disease. Diabetes mellitus was induced in 48 Wistar rats by intraperitoneal injection of streptozotocin (80 mg/kg). After confirming the diabetes diagnosis, the animals were treated with β-glucans (by gavage) for 28 days. On the 14th day of this period, periodontal disease was induced using a ligature protocol. β-glucans reduced the amount of alveolar bone loss in animals with periodontal disease in both the diabetic and non-diabetic groups (p < 0.05). β-glucans reduced blood glucose, cholesterol and triacylglycerol levels in diabetic animals, both with and without periodontal disease (p < 0.05). Furthermore, treatment with β-glucans reduced the expression of cyclooxygenase-2 and receptor activator of nuclear factor kappa-B ligand and increased osteoprotegerin expression in animals with diabetes and periodontal disease (p < 0.05). It was concluded that treatment with β-glucans has beneficial metabolic and periodontal effects in diabetic rats with periodontal disease.