Plasma Procalcitonin Is Associated with Obesity, Insulin Resistance, and the Metabolic Syndrome
Plasma Procalcitonin Is Associated with Obesity, Insulin Resistance, and the Metabolic Syndrome
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DOI：
10.1210/jc.2010-0305
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发表时间：
2010-09-01
影响因子：
5.8
通讯作者：
Bakker, Stephan J. L.
中科院分区：
文献类型：
--
作者：
Abbasi, Ali;Corpeleijn, Eva;Bakker, Stephan J. L.
背景：降钙素原是一种众所周知的脓毒症和细菌感染的生物标志物，由脂肪组织产生，有可能作为慢性低度炎症的标志物。目的：本研究的目的是调查正常范围内的血浆降钙素原水平是否与普通人群的肥胖、胰岛素抵抗和代谢综合征（MS）相关。方法：采用超灵敏免疫荧光测定法对3197名男性和3638名女性（年龄28-75岁）进行血浆降钙素原（0.006-0.1 ng/ml）测定。根据成人治疗组III标准定义多发性硬化症。结果：血浆降钙素原男性为0.018 (0.015-0.022)ng/ml，女性为0.014 (0.012-0.017)ng/ml
Context: Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation.Objectives: The objective of this study was to investigate whether plasma procalcitonin levels in the normal range are associated with obesity, insulin resistance, and metabolic syndrome (MS) in the general population.Methods: Plasma procalcitonin (0.006-0.1 ng/ml) was measured in 3197 men and 3638 women (aged 28-75 yr) of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study using an ultra-sensitive immunoluminometric assay. MS was defined according to Adult Treatment Panel III criteria.Results: Median (interquartile range) plasma procalcitonin was 0.018 (0.015-0.022) ng/ml in men and0.014 (0.012-0.017) ng/ml inwomen(P