Two way communication between neutrophils and dendritic cells
Two way communication between neutrophils and dendritic cells
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DOI：
10.1016/j.coph.2006.03.009
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发表时间：
2006-08-01
影响因子：
4
通讯作者：
van Kooyk, Yvette
中科院分区：
文献类型：
--
作者：
Ludwig, Irene S.;Geijtenbeek, Teunis B. H.;van Kooyk, Yvette
中性粒细胞通过介导立即清除病原体而有助于先天免疫。最近的研究结果表明，它们能够与树突状细胞进行交流，树突状细胞通过刺激长期记忆 T 细胞反应，在先天性免疫和适应性免疫之间建立联系。这种通讯通过细胞表面受体 Mac-1 和中性粒细胞上的癌胚抗原相关细胞粘附分子发生，这些分子与 C 型凝集素（例如树突状细胞特异性 ICAM-3 抓取非整合素 (DC-SIGN)）相互作用。显然，树突状细胞可以延长中性粒细胞的寿命，而中性粒细胞可以指导树突状细胞介导的 T 细胞反应。
Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the cell-surface receptors Mac-1 and carcinoembryonic antigen-related cellular adhesion molecule on neutrophils, which interact with C-type lectins such as dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN). Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses.