Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia.
Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia.
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DOI：
10.3389/neuro.07.007.2007
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发表时间：
2007
影响因子：
3.5
通讯作者：
Blusztajn, Jan Krzysztof
中科院分区：
文献类型：
--
作者：
Meck, Warren H;Williams, Christina L;Cermak, Jennifer Marie;Blusztajn, Jan Krzysztof
为了确定大脑和行为对早期发育过程中可能充当诱导信号的营养物质的敏感性，我们改变了大鼠在胚胎第6天（ED）到出生后第75天（PD）75天的7个时间范围内的胆碱可用性，并检查了围产期治疗的成年大鼠的空间记忆能力。确定了两个敏感期，即 ED 12-17 和 PD 16-30，在此期间补充胆碱促进了空间记忆，并增加了海马 CA1 和齿状回 (DG) 区域的树突棘密度，同时也改变了 DG 颗粒细胞的树突状区域。此外，仅在 ED 12-17 期间补充胆碱，可以防止通常在老年大鼠中观察到的记忆力下降。这些行为变化与刺激释放后海马切片的乙酰胆碱（ACh）含量密切相关。我们的数据表明，大脑发育关键时期胆碱的可用性会影响成年期和老年期的认知表现，并强调围产期营养对于成功认知衰老的重要性。
In order to determine brain and behavioral sensitivity of nutrients that may serve as inductive signals during early development, we altered choline availability to rats during 7 time frames spanning embryonic day (ED) 6 through postnatal day (PD) 75 and examined spatial memory ability in the perinatally-treated adults. Two sensitive periods were identified, ED 12–17 and PD 16–30, during which choline supplementation facilitated spatial memory and produced increases in dendritic spine density in CA1 and dentate gyrus (DG) regions of the hippocampus while also changing the dendritic fields of DG granule cells. Moreover, choline supplementation during ED 12–17 only, prevented the memory decline normally observed in aged rats. These behavioral changes were strongly correlated with the acetylcholine (ACh) content of hippocampal slices following stimulated release. Our data demonstrate that the availability of choline during critical periods of brain development influences cognitive performance in adulthood and old age, and emphasize the importance of perinatal nutrition for successful cognitive aging.