Role for gamma-aminobutyric acid in selective vulnerability in gerbils.
Role for gamma-aminobutyric acid in selective vulnerability in gerbils.
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DOI：
10.1161/01.str.20.2.281
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发表时间：
1989-02
期刊：
影响因子：
8.3
通讯作者：
Linda L. Sternau;W. Lust;Anthony J. Ricci;Robert Ratcheson
中科院分区：
文献类型：
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作者：
Linda L. Sternau;W. Lust;Anthony J. Ricci;Robert Ratcheson
我们测试了各种假定的神经保护剂在沙鼠迟发性神经元死亡模型中的功效。双侧缺血5分钟后4天，在90%以上的沙鼠中，海马前CA1区神经元的选择性丢失是完全的。我们测试了11种药物对神经元损失的保护能力。只有那些与GABA能系统相关的药物才表现出保护作用，并且只有在缺血性损伤前给药时才表现出保护作用。迟发性神经元死亡的可能性，被认为是抑制性神经传递的主要缺陷的结果。
We tested the efficacy of various putative neuroprotective agents in the gerbil model of delayed neuronal death. The selective loss of anterior CA1 neurons of the hippocampus 4 days after 5 minutes of bilateral ischemia was complete in greater than 90% of the gerbils examined. We tested 11 agents for their ability to protect against neuronal loss. Only those agents that were associated with the GABAergic system exhibited protection and only when administered before the ischemic insult. The possibility that delayed neuronal death is the result of a primary defect in inhibitory neurotransmission is considered.