Exercise training improves neurovascular control and functional capacity in heart failure patients regardless of age
Exercise training improves neurovascular control and functional capacity in heart failure patients regardless of age
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DOI：
10.1177/1741826711414626
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发表时间：
2012-08-01
影响因子：
8.3
通讯作者：
Negrao, Carlos E.
中科院分区：
文献类型：
--
作者：
Antunes-Correa, Ligia M.;Kanamura, Bianca Y.;Negrao, Carlos E.
背景：运动训练是治疗心力衰竭的非药物策略。运动训练可提高患者的功能能力和生活质量。此外，运动训练会减少肌肉交感神经活动（MSNA）和周围血管收缩。然而，这些研究大多数是在中年患者中进行的。因此，运动训练对老年患者的影响知之甚少。本研究旨在调查运动训练是否可以像中年心力衰竭患者一样改善老年心力衰竭患者的功能能力、肌肉交感神经激活和肌肉血流量。 设计：心血管康复和生理学单位数据库中连续 52 例心力衰竭门诊患者按年龄（中年，定义为 45-59 岁，老年，定义为 60-75 岁）和运动状态进行划分（经过训练和未经训练）。方法：使用显微神经造影技术直接从腓神经记录 MSNA。通过静脉阻塞体积描记法测量前臂血流量（FBF）。通过心肺运动试验评估功能能力。结果：运动训练显着且相似地增加了中老年心力衰竭患者的FBF和峰值VO2。此外，运动训练同样显着降低了这些患者的 MSNA 和前臂血管阻力。在未经训练的患者中没有发现显着的变化。结论：运动训练可以改善心力衰竭患者的神经血管控制和功能能力，无论年龄如何。
Background: Exercise training is a non-pharmacological strategy for treatment of heart failure. Exercise training improves functional capacity and quality of life in patients. Moreover, exercise training reduces muscle sympathetic nerve activity (MSNA) and peripheral vasoconstriction. However, most of these studies have been conducted in middle-aged patients. Thus, the effects of exercise training in older patients are much less understood. The present study was undertaken to investigate whether exercise training improves functional capacity, muscular sympathetic activation and muscular blood flow in older heart failure patients, as it does in middle-aged heart failure patients.Design: Fifty-two consecutive outpatients with heart failure from the database of the Unit of Cardiovascular Rehabilitation and Physiology Exercise were divided by age (middle-aged, defined as 45-59 years, and older, defined as 60-75 years) and exercise status (trained and untrained).Methods: MSNA was recorded directly from the peroneal nerve using the microneurography technique. Forearm Blood Flow (FBF) was measured by venous occlusion plethysmography. Functional capacity was evaluated by cardiopulmonary exercise test.Results: Exercise training significantly and similarly increased FBF and peak VO2 in middle-aged and older heart failure patients. In addition, exercise training significantly and similarly reduced MSNA and forearm vascular resistance in these patients. No significant changes were found in untrained patients.Conclusion: Exercise training improves neurovascular control and functional capacity in heart failure patients regardless of age.