THE HEALING OF SUPERFICIAL SKIN WOUNDS IS STIMULATED BY EXTERNAL ELECTRICAL-CURRENT
THE HEALING OF SUPERFICIAL SKIN WOUNDS IS STIMULATED BY EXTERNAL ELECTRICAL-CURRENT
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DOI：
10.1111/1523-1747.ep12543498
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发表时间：
1983-01-01
影响因子：
6.5
通讯作者：
EAGLSTEIN, WH
中科院分区：
文献类型：
--
作者：
ALVAREZ, OM;MERTZ, PM;EAGLSTEIN, WH
研究了镀银电极通电对真皮和表皮创面愈合的影响。用50-300µA加压电极(DC)、不加电电极(安慰剂)或不加电电极(安慰剂)治疗角膜刀在幼龄家猪皮肤上造成的0.3 mm深的伤口。伤后1~7天切除创面，分离真皮和表皮。评估表皮的再上皮化情况，并检测真皮的胶原生物合成能力。在伤后1-4天，各处理组真皮胶原的产生无明显差异。在第5、6和7天，DC处理的创面的胶原合成能力显著增加(P<；0.001)。当胶原合成根据DNA含量进行校正时，不同处理之间的胶原合成没有显著差异。DC处理的创面上皮化速度也显著加快(P<；0.05)。参与修复和再生的上皮和结缔组织细胞的增殖和/或迁移能力可能会受到电场的影响。
The effects of direct electric current supplied by an energized silver-coated electrode on dermal and epidermal wound healing was studied. Keratome-induced wounds (0.3 mm deep) on the skin of young domestic pigs were treated with either an energized (50-300 .mu.A) electrode (DC), an unenergized electrode (placebo), or left untreated. Wounds were excised on days 1-7 after wounding and the epidermis was separated from the dermis. The epidermal sheet was evaluated for reepithelialization and the dermis was assayed for collagen biosynthetic capacity. Dermal collagen production among treatments did not differ markedly on days 1-4 after wounding. A highly significant increase (P < 0.001) in the collagen synthetic capacity was observed on days 5, 6, and 7 in wounds treated with DC. There was no significant difference in collagen synthesis among treatments when collagen production was corrected for DNA content. The rate of wound epithelization was also significantly accelerated (P < 0.05) in DC-treated wounds. Probably the proliferative and/or migratory capacity of epithelial and connective tissue cells involved in repair and regeneration can be affected by an electrical field.