CANCER RISK DUE TO OCCUPATIONAL EXPOSURE TO POLYCYCLIC AROMATIC-HYDROCARBONS
CANCER RISK DUE TO OCCUPATIONAL EXPOSURE TO POLYCYCLIC AROMATIC-HYDROCARBONS
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DOI：
10.1002/ajim.4700280302
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发表时间：
1995-09-01
影响因子：
3.5
通讯作者：
GERIN, M
中科院分区：
文献类型：
--
作者：
NADON, L;SIEMIATYCKI, J;GERIN, M
多环芳烃(PAHs)在动物模型中显示出致癌活性。尽管一些流行病学研究表明多环芳烃是人类癌症的危险因素，但迄今为止报道的证据并不一致。本报告的目的是描述工作场所职业性暴露于多环芳烃与14种癌症之间的关系。在蒙特利尔进行了一项以人群为基础的病例对照研究，以调查各种环境和职业暴露与几种癌症之间的关系。从每个受试者那里获得了详细的工作经历，以及关于一些潜在混杂因素的信息。每个工作历史都由一个专家团队审查，他们使用这些信息来构建相应的职业暴露历史。在考虑的多环芳烃暴露中包括苯并(A)芘(B(A)P)和根据来源材料界定的五类多环芳烃，即木材、石油、煤炭、其他来源和任何来源。总共采访了3730名癌症患者和533名对照人群，并对他们的工作接触史进行了编码。对于所分析的14种癌症中的每一种，都有三个对照组：其他癌症患者，人口对照组，以及癌症和人口对照组的集合。用Logistic回归方法分析了14种癌症类型与6种多环芳烃暴露的关系。就所评估的大多数癌症类型而言，没有证据表明在蒙特利尔地区暴露于多环芳烃的职业中所遇到的多环芳烃水平存在超额风险。对于一些癌症部位--食道、胰腺和前列腺癌--存在风险过高的迹象；这些观察结果是值得注意的进一步研究的假设。在肺癌方面，由于PAHs在非吸烟者和轻度吸烟者中似乎增加了风险，但在重度吸烟者中并非如此。(C)1995年Wiley-Liss公司
Polycyclic aromatic hydrocarbons (PAHs) demonstrate carcinogenic activity in animal models. Although some epidemiologic studies have implicated PAHs as risk factors for human cancer, the evidence reported to date has not been consistent. The purpose of this report is to describe the associations between occupational exposure to PAHs in the workplace and each of 14 types of cancer. A population-based, case-control study was carried out in Montreal to investigate associations between a large variety of environmental and occupational exposures on the one hand, and several types of cancer on the other. A detailed job history was obtained from each subject along with information on a number of potential confounders. Each job history was reviewed by a team of experts, who used this information to construct a corresponding history of occupational exposures. Among the PAH exposures considered were benzo(a)pyrene (B(a)P) and five categories of PAHs defined on the basis of the source material, namely, wood, petroleum, coal, other sources, and any source. Altogether, 3,730 cancer patients and 533 population controls were interviewed and their job exposure histories coded. For each of 14 types of cancer analyzed, three control groups were available: other cancer patients, population controls, and the pooled set of cancer and population controls. The associations between 14 cancer types and 6 PAH exposures were analyzed using logistic regression methods. For most types of cancer evaluated, there was no evidence of excess risk due to PAHs at the levels encountered in the occupations in which PAH exposure has been prevalent in the Montreal area. For a few cancer sites-the esophagus, the pancreas, and the prostate gland-there were suggestions of excess risk; these observations are noteworthy hypotheses for further investigation. For lung cancer, there appeared to be an increased risk due to PAHs among nonsmokers and light smokers, but not among heavy smokers. (C) 1995 Wiley-Liss, Inc.