Interstitial cells of the bladder: the missing link?
Interstitial cells of the bladder: the missing link?
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DOI：
10.1111/j.1471-0528.2004.00469.x
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发表时间：
2004-12-01
影响因子：
5.8
通讯作者：
De Ridder, D
中科院分区：
文献类型：
--
作者：
Blyweert, W;Van der Aa, F;De Ridder, D
膀胱壁的神经支配和功能仍然有些神秘。已经提出了膀胱过度活动的不同病因机制。神经源性原因是众所周知的。然而，对于特发性形式，解释仍有待建立。以前的研究人员集中在传出和传入神经支配和平滑肌生理学;最近的研究论文显示，兴趣的转移到urothorax和sububurothorax的作用。尿道的传感功能正在调查，以及一种奇怪的类型的肌纤维母细胞样或间质细胞的作用，位于尿道下裂和逼尿肌bundle.In本文中，作者试图整合目前的数据在一个有趣的假设。如果这些间质细胞被证明在整合来自尿道和神经的信息中起作用，它们将能够调节逼尿肌收缩力;这将意味着我们对膀胱过度活动的理解向前迈进了一大步。由于类似的细胞也存在于肠道和其他器官中，粘膜衬里和底层平滑肌之间的相互作用可能成为一个有趣的研究领域。
The innervation and function of the bladder wall is still somewhat enigmatic. Different aetiological mechanisms for bladder overactivity have been proposed. Neurogenic causes are well known. For the idiopathic forms, however, explanations remain to be established. Previously researchers have focused on efferent and afferent innervation and on smooth muscle physiology; recent research papers show a shift of interest to the role of the urothelium and the suburothelium. The sensing function of the urothelium is being investigated as well as the role of a strange type of myofibroblast-like or interstitial cell, located in the suburothelium and in between detrusor muscle bundles.In this paper the authors try to integrate the current data in an intriguing hypothesis. If these interstitial cells prove to have a role in integrating the information coming from the urothelium and nerves they would be able to modulate detrusor contractility; this would mean a leap forward in our understanding of bladder overactivity. Since similar cells are also present in the gut and other organs, the interaction between the mucosal lining and the underlying smooth muscle might become an interesting research area.