Reduced striatal activation in females with major depression during the processing of affective stimuli
Reduced striatal activation in females with major depression during the processing of affective stimuli
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DOI：
10.1016/j.jpsychires.2015.04.025
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发表时间：
2015-09-01
影响因子：
4.8
通讯作者：
Wang, Xue
中科院分区：
文献类型：
--
作者：
Connolly, Megan E.;Gollan, Jackie K.;Wang, Xue
抑郁症对情感反应和相关神经基础的改变程度仍然是模棱两可的。这项研究评估了 51 名未接受药物治疗且符合 DSM-IV 重度抑郁症 (MDD) 标准的女性参与者和 61 名年龄匹配的 17-63 岁健康女性 (HC) 的纹状体激活情况。参与者完成了情感反应功能磁共振成像任务。使用 SPM8 预处理数据，并使用 MarsBaR 完成感兴趣区域分析，以提取尾状核、壳核和伏隔核 (NAcc) 激活。一般线性重复测量方差分析用于评估组间差异，相关分析用于测量激活、抑郁严重程度和快感缺乏之间的关联。观察到半球、效价和群体状态的主要影响，与 HC 相比，MDD 参与者表现出纹状体激活减少。在不同群体和价态类型中，左半球在壳核和伏核中表现出比右半球更大的激活，而右半球在尾状核中表现出比左半球更大的激活。此外，不愉快的刺激比愉快和中性刺激在尾状核和壳核中引起更大的激活，并且不愉快的刺激在NAcc中比中性刺激引起更大的激活。激活、抑郁严重程度和快感缺乏之间没有显着关联。总体而言，抑郁症的特点是纹状体情感反应性降低，无论刺激效价如何，支持抑郁症的情绪背景不敏感模型。 (C) 2015 Elsevier Ltd. 保留所有权利。
The extent to which affective reactivity and associated neural underpinnings are altered by depression remains equivocal. This study assessed striatal activation in fifty-one unmedicated female participants meeting DSM-IV criteria for Major Depressive Disorder (MDD) and 61 age-matched healthy females (HC) aged 17-63 years. Participants completed an affective reactivity functional magnetic resonance imaging task. Data were preprocessed using SPM8, and region-of-interest analyses were completed using MarsBaR to extract caudate, putamen, and nucleus accumbens (NAcc) activation. General linear repeated measure ANOVAs were used to assess group differences and correlational analyses were used to measure the association between activation, depression severity, and anhedonia. Main effects of hemisphere, valence, and group status were observed, with MDD participants demonstrating decreased striatal activation compared with HC. Across groups and valence types, the left hemisphere demonstrated greater activation than the right hemisphere in the putamen and nucleus accumbens, whereas the right hemisphere demonstrated greater activation than the left in the caudate. Additionally, unpleasant stimuli elicited greater activation than pleasant and neutral stimuli in the caudate and putamen, and unpleasant stimuli elicited greater activation than neutral stimuli in the NAcc. There were no significant associations between activation, depression severity, and anhedonia. Overall, depression was characterized by reduced affective reactivity in the striatum, regardless of stimuli valence, supporting the emotion context insensitivity model of depression. (C) 2015 Elsevier Ltd. All rights reserved.