The molecular structure of the liquid-ordered phase of lipid bilayers.
The molecular structure of the liquid-ordered phase of lipid bilayers.
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DOI：
10.1021/ja4105667
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发表时间：
2014-01-15
影响因子：
15
通讯作者：
Lyman E
中科院分区：
文献类型：
--
作者：
Sodt AJ;Sandar ML;Gawrisch K;Pastor RW;Lyman E
分子动力学模拟揭示了脂双层有序液相内的亚结构。这些亚结构，在10 μsec的液体有序/液体无序共存（Lo/Ld）的全原子轨迹中确定，由具有局部六方有序的饱和烃链组成，并被富含胆固醇和不饱和链的间隙区域隔开。从Lo相计算的脂烃链序参数与2 H NMR测量结果非常一致;局部六方堆积也与Lo相的1H-MAS NMR光谱、NMR扩散实验以及小角X射线和中子散射一致。平衡的胆固醇丰富的本地六角秩序提出控制膜组件的分区到Lo区域。后者经常与所谓的筏的形成有关，筏是细胞质膜中的平台，有助于信号通路组分之间的相互作用。
Molecular dynamics simulations reveal substructures within the liquid-ordered phase of lipid bilayers. These substructures, identified in a 10 μsec all-atom trajectory of liquid-ordered/liquid-disordered coexistence (Lo/Ld), are composed of saturated hydrocarbon chains packed with local hexagonal order, and separated by interstitial regions enriched in cholesterol and unsaturated chains. Lipid hydrocarbon chain order parameters calculated from the Lo phase are in excellent agreement with 2H NMR measurements; the local hexagonal packing is also consistent with 1H-MAS NMR spectra of the Lo phase, NMR diffusion experiments, and small angle X-ray- and neutron scattering. The balance of cholesterol-rich to local hexagonal order is proposed to control the partitioning of membrane components into the Lo regions. The latter have been frequently associated with formation of so-called rafts, platforms in the plasma membranes of cells that facilitate interaction between components of signaling pathways.
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影响因子：
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作者：
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