MRI Methods for Imaging Beta-Cell Function in the Rodent Pancreas.
MRI Methods for Imaging Beta-Cell Function in the Rodent Pancreas.
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啮齿动物胰腺 β 细胞功能成像的 MRI 方法。
DOI：
10.1007/978-1-0716-2807-2_7
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Sherry,ADean
中科院分区：
文献类型：
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作者：
Khalighinejad,Pooyan;Suh,EulHyun;Sherry,ADean
Zn 2+离子在β-细胞颗粒中胰岛素的适当储存中的作用是公认的，因此当胰岛素从由血糖增加刺激的β-细胞分泌时，游离Zn 2+离子也被释放。通过使用锌响应MR造影剂，可以在啮齿动物胰腺中真实的检测到Zn 2+的这种局部增加。这种方法提供了纵向监测活体啮齿动物β细胞功能的机会。在我们的实验室中使用的方法充分描述在这个简短的报告和一些MR图像的大鼠胰腺显示明显增强的热点在尾部。
The role of Zn2+ions in proper storage of insulin in β-cell granules is well-established so when insulin is secreted from β-cells stimulated by an increase in plasma glucose, free Zn2+ions are also released. This local increase in Zn2+can be detected in the pancreas of rodents in real time by the use of a zinc-responsive MR contrast agent. This method offers the opportunity to monitor β-cell function longitudinally in live rodents. The methods used in our lab are fully described in this short report and some MR images of a rat pancreas showing clearly enhanced hot spots in the tail are presented.