Calculation of LD50 values from the method of Miller and Tainter, 1944.
Calculation of LD50 values from the method of Miller and Tainter, 1944.
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根据 Miller 和 Tainter，1944 年的方法计算 LD50 值。
DOI：
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发表时间：
2009
期刊：
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通讯作者：
M. A. Randhawa
中科院分区：
文献类型：
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作者：
M. A. Randhawa
尊敬的编辑，药物的急性毒性可以通过计算LD 50来确定，即，能杀死50%特定物种动物的剂量。最近，我们通过米勒和Tainter（1944）描述的方法，报告了百里醌（黑种草的一种活性成分）在小鼠和大鼠中的LD 50。从那时起，一些研究生和研究人员要求我们解释通过这种方法计算LD 50的细节，因为原始文章非常古老，在文献中不易获得。我们在计算中也遇到了问题，然而，我们在Ghosh的实验药理学基础中发现了一些计算LD 50的细节，这在世界上许多地方也不容易获得。因此，很少写行，代表其他作者，阐述计算LD 50的方法，米勒和泰恩特为年轻的研究人员的利益。
Dear Editor, Acute toxicity of a drug can be determined by the calculation of LD50, i.e., the dose that will kill 50% of animals of a particular species. Recently, we reported the LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats by the method described by Miller and Tainter, 1944. Since then some post-graduate students and investigators have asked us to explain the details of calculation of LD50 by this method, as the original article, being very old, is not easily available in the literature. We also faced problem in the calculations, however, we found some details for the calculation of LD50 in the Fundamentals of Experimental Pharmacology by Ghosh, which also is not easy to obtain in many parts of the world. Therefore, few lines are written, on behalf of the other authors, to elaborate the calculation of LD50 by the method of Miller and Tainter for the benefit of young researchers.