Type III IFNs: New layers of complexity in innate antiviral immunity
Type III IFNs: New layers of complexity in innate antiviral immunity
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DOI：
10.1002/biof.19
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发表时间：
2009-01-01
期刊：
影响因子：
6
通讯作者：
Paludan, Soren R.
中科院分区：
文献类型：
--
作者：
Ank, Nina;Paludan, Soren R.
细胞因子是一种分泌型小分子，介导细胞间的相互作用，参与免疫应答。干扰素（IFN）是一类具有抗病毒活性的细胞因子，其中Ⅰ型IFN在先天性抗病毒应答中起着特别重要的作用。(also称为IFN-λ或白细胞介素28/29）代表一类具有与I型IFN相似的生物活性的新型细胞因子，但似乎通过主要在上皮表面发挥宿主保护作用而在抗病毒防御中具有更专门的作用。在这篇综述中，我们描述了目前的知识III型干扰素在抗病毒防御中的作用。(C)2009年国际生物化学与分子生物学联合会第35卷，第1期，2009年1月/2月，第82-87页。电子邮件地址：srp@microbiology.au.dk
Cytokines are small secreted molecules, which mediated cross-talk between cells involved in the immune response Interferon's (IFN)s, constitute a class of cytokines antiviral activities, and the type I IFNs have been ascribed particularly important roles in, the innate antiviral response Type III IFNs.(also known as IFN-lambda or interleukin 28/29) represent a class of novel cytokines with biological activities similar to the type I IFNs, but seem to have a more specialized role in antiviral defense by exerting host-protection primarily at epithelial surfaces. In this review, we describe the current knowledge on the role of type III IFNS in antiviral defense.(C) 2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 1, January/February 2009, Pages 82-87. E-mail: srp@microbiology.au.dk