Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents
Retinal vascular integrity following correction of diabetic ketoacidosis in children and adolescents
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DOI：
10.1016/j.jdiacomp.2004.08.005
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发表时间：
2005-07-01
影响因子：
3
通讯作者：
Dalton, RR
中科院分区：
文献类型：
--
作者：
Martin, SLA;Hoffman, WH;Dalton, RR
目的：糖尿病酮症酸中毒（DKA）治疗过程中，脑微血管通透性增加。在DKA治疗前后报告了与糖尿病视网膜病变一致的微血管变化。本研究评价了DKA矫正后视网膜的结构和功能方面。研究方法：7例年轻患者在重度DKA（pH < 7.2）纠正后24 h内进行了全面的眼科检查，包括荧光素血管造影。结果：所有患者均无视网膜异常的临床、影像学或血管造影证据。结论：血-视网膜屏障（BRB）不经历与血-脑屏障（BBB）相同程度的扰动，并且在DKA损伤及其治疗期间可能是受保护的部位。视网膜微血管系统的更大稳定性可能是由于与BBB相比，BRB中周细胞的数量增加。(c)2005年爱思唯尔公司All rights reserved.
Objective: Increased permeability of the cerebral microvasculature occurs during the treatment of diabetic ketoacidosis (DKA). Microvascular changes consistent with diabetic retinopathy have been reported prior to and after the treatment of DKA. This study evaluated the structural and functional aspects of the retina immediately following the correction of DKA. Methods: Seven young patients had comprehensive ophthalmologic examinations, including fluorescein angiography, within 24 h after the correction of severe DKA (pH < 7.2). Results: None of the patients had clinical, photographic, or angiographic evidence of a retinal abnormality. Conclusion: The blood-retinal barrier (BRB) does not experience the same degree of perturbation as the blood-brain barrier (BBB) does and may be a protected site during the insult of DKA and its treatment. The greater stability of the retinal microvasculature may be due to the increased number of pericytes in the BRB in comparison with the BBB. (c) 2005 Elsevier Inc. All rights reserved.