Dynamic changes in N-terminal pro-brain natriuretic peptide in acute coronary syndromes treated with percutaneous coronary intervention: a marker of ischemic burden, reperfusion and outcome
Dynamic changes in N-terminal pro-brain natriuretic peptide in acute coronary syndromes treated with percutaneous coronary intervention: a marker of ischemic burden, reperfusion and outcome
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DOI：
10.1515/cclm.2010.164
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发表时间：
2010-06-01
影响因子：
6.8
通讯作者：
Luchner, Andreas
中科院分区：
文献类型：
--
作者：
Buchner, Stefan;Debl, Kurt;Luchner, Andreas
Background: Whereas N-terminal pro-brain natriuretic peptide (NT-proBNP) is approved for risk stratification of patients with acute coronary syndromes (ACS), short-term temporal changes in NT-proBNP concentrations and the optimal time points for sampling are not clear. The purpose of this study was to better define the short-term changes in NT-proBNP in relation to clinical presentation, reperfusion and prognostic value in patients with ACS, as well as to identify the optimum time points for sampling.Methods: We studied daily plasma concentrations of NT-proBNP in 133 unselected patients with myocardial infarction (n = 65), stable coronary artery disease (CAD, n = 46) and no CAD (n = 22) who underwent coronary angiography.Results: Patients with non-ST-elevation myocardial infarction (NSTEMI) presented with markedly higher NT-proBNP than patients with ST-elevation myocardial infarction (STEMI) [1305 (741-3208) ng/L vs. 170 (70-424) ng/L, p < 0.001]. Also, time to presentation from onset of pain was much longer in NSTEMI as compared to STEMI (> 48 h vs.
