Switching to antipsychotic monotherapy can improve attention and processing speed, and social activity in chronic schizophrenia patients
Switching to antipsychotic monotherapy can improve attention and processing speed, and social activity in chronic schizophrenia patients
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DOI：
10.1016/j.jpsychires.2013.08.024
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发表时间：
2013-12-01
影响因子：
4.8
通讯作者：
Nakamura, Jun
中科院分区：
文献类型：
--
作者：
Hori, Hikaru;Yoshimura, Reiji;Nakamura, Jun
目的：方法：将39例接受两种抗精神病药物治疗的精神分裂症患者随机分为转换组（转换组）和继续组（继续组），每组39例。对于分配到转换组的患者，两种抗精神病药物之一的剂量水平逐渐降低至零。精神症状，认知功能和社会功能量表评分进行了评估，立即切换前和24周后，这些分数的时间过程进行了比较两组之间的比较：结果：与继续组相比，切换组表现出显着更大的改善后，切换（p = 0.02）的注意力。此外，转换组的日常生活（p = 0.038）和工作技能（p = 0.04）改善显著更大。在对改善程度的子项目之间的相关性进行分析时，注意到执行功能的改善与日常生活的改善之间存在显著相关性（r =-0.64，p = 0.005）以及工作技能的提高与注意力的提高之间的关系结论：在接受多种药物治疗的精神分裂症患者中，转换为单药治疗可改善注意力。此外，执行功能的改善导致日常生活的改善，注意力的改善导致工作技能的改善。因此，转换为单药治疗是一个有用的选择。(C)2013爱思唯尔有限公司保留所有权利。
Objective: This study sought to examine whether switching polypharmacy therapy to monotherapy would improve the cognitive function and social function of patients with schizophrenia.Methods: Thirty-nine patients with schizophrenia who were receiving therapy with two antipsychotics were randomly divided into a switch to monotherapy group (switching group) and a polypharmacy continued group (continuing group). For the patients allocated to the switching group, the dose level of one of the two antipsychotic drugs was gradually reduced to zero. Psychotic symptoms, cognitive function and social function scale scores were assessed immediately before and 24 weeks after switching, and the time courses of these scores were compared between the two groups.Results: Compared with the continuing group, the switching group demonstrated significantly greater improvement in attention after switching (p = 0.02). Furthermore, the improvement in daily living (p = 0.038) and work skills (p = 0.04) was significantly greater in the switching group. In an analysis of the correlation among sub-items with respect to the degrees of improvement, a significant correlation was noted between improvement in executive function and improvement in daily living (r = -0.64, p = 0.005) and between improvement in work skills and improvement in attention (r = -0.51, p = 0.038).Conclusion: In patients with schizophrenia receiving polypharmacy, switching to monotherapy resulted in improvements in attention. Furthermore, improvements in executive function led to improvements in daily living, and improvements in attention led to improvements in work skills. Thus, switching to monotherapy is a useful option. (C) 2013 Elsevier Ltd. All rights reserved.