Interleukin-22 upregulates HB-EGF expression in HaCaT cells via JAK2/STAT3 and ERK1/2 signalling
Interleukin-22 upregulates HB-EGF expression in HaCaT cells via JAK2/STAT3 and ERK1/2 signalling
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DOI：
10.1111/exd.12736
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发表时间：
2015-09-01
影响因子：
3.6
通讯作者：
Liu, Quanzhong
中科院分区：
文献类型：
--
作者：
Luo, Suju;Liu, Xinxin;Liu, Quanzhong
该文章探讨了白细胞介素 (IL)-22 对 HaCaT 角质形成细胞中肝素结合表皮生长因子 (HB-EGF) 表达和增殖的影响。使用 IL-22，不同浓度的 HaCaT 细胞增殖都会受到刺激。通过使用小干扰 RNA 敲低 IL-22 的表达，证实了 IL-22 的增殖诱导作用。 IL-22 处理后，HaCaT 细胞中 HB-EGF 信使 RNA (mRNA) 和蛋白质水平显着增加。
The article examines the effects of the interleukin (IL)-22 on the expression and proliferation of heparin-binding-epidermal growth factor (HB-EGF) in HaCaT keratinocytes. With IL-22, HaCaT cell proliferation is stimulated at different concentrations. The proliferation-inducing role of IL-22 is confirmed by knocking down its expression using small interfering RNA. A significant increase in HB-EGF messenger RNA (mRNA) and protein levels in HaCaT cells is also noted following IL-22 treatment.