Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients
Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients
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DOI：
10.1038/sj.onc.1207069
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发表时间：
2004-01-15
期刊：
影响因子：
8
通讯作者：
Srivastava, S
中科院分区：
文献类型：
--
作者：
Petrovics, G;Zhang, W;Srivastava, S
PCGEM 1是一个新的、高度前列腺组织特异性的、雄激素调节的基因。在这里，我们证明，PCGEM 1的表达是显着较高的前列腺癌（CaP）细胞的非洲裔美国男性比高加索裔美国男性（P=0.0002）。此外，PCGEM 1表达增加与具有CaP家族史的CaP患者的正常前列腺上皮细胞相关（P=0.0400）。PCGEM 1在LNCaP和NIH 3 T3细胞中的过表达促进细胞增殖和集落形成的显著增加，表明PCGEM 1在细胞生长调节中的生物学作用。总之，PCGEM 1的细胞增殖/集落形成促进功能及其表达增加与高危CaP患者的相关性表明PCGEM 1在CaP发病/进展中的潜在作用，特别是在这些高危人群中。
PCGEM1 is a novel, highly prostate tissue-specific, androgen-regulated gene. Here, we demonstrate that PCGEM1 expression is significantly higher in prostate cancer (CaP) cells of African-American men than in Caucasian-American men (P=0.0002). Further, increased PCGEM1 expression associates with normal prostate epithelial cells of CaP patients with a family history of CaP (P=0.0400). PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation. Taken together, the cell proliferation/colony formation-promoting functions of PCGEM1 and the association of its increased expression with high-risk CaP patients suggest the potential roles of PCGEM1 in CaP onset/progression, especially in these high-risk groups.