Interactions of fibronectin with streptococci: the role of fibronectin as a receptor for Streptococcus pyogenes.
Interactions of fibronectin with streptococci: the role of fibronectin as a receptor for Streptococcus pyogenes.
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纤连蛋白与链球菌的相互作用：纤连蛋白作为化脓性链球菌受体的作用。
DOI：
10.1093/clinids/9.supplement_4.s351
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Ofek,I
中科院分区：
文献类型：
--
作者：
Simpson,WA;Courtney,HS;Ofek,I
目前的证据表明，化脓性链球菌表面的脂磷壁酸（LTA）主要参与这些细菌对口腔粘膜的粘附。口腔粘膜细胞表面S.化脓性纤维连接蛋白纤连蛋白是一种复杂的糖蛋白，存在于血液、细胞外基质和唾液中。许多种链球菌与纤连蛋白结合，尽管这些相互作用的特征不同。此外，LTA是纤连蛋白与A组链球菌结合的有效抑制剂，但它几乎没有抑制纤连蛋白与肺炎链球菌或金黄色葡萄球菌结合的能力。用纤连蛋白进行的研究表明，不同的细菌与不同的位点结合。各种细菌与纤连蛋白分子上不同结构域相互作用的能力可能在细菌粘附和组织嗜性中起重要作用。
Current evidence suggests that lipoteichoic acid (LTA) on the surface ofStreptococcus pyogenesiscentrally involved in the adherence of these bacteria to the oral mucosa. The major receptor on the surface of buccal mucosal cells forS. pyogenesis fibronectin. Fibronectin is a complex glycoprotein found in blood, extracellular matrices, and saliva. Many species of streptococci bind to fibronectin, although the characteristics of these interactions are different. Furthermore, whereas LTAis an efficient inhibitor of the binding of fibronectin to group A streptococci, it has little ability to inhibit the binding of fibronectin toStreptococcus pneumoniaeorStaphylococcus aureus. Studies conducted with fibronectin show that different bacteria bind to different sites. The ability of various bacteria to interact with different domains on the fibronectin molecule may play an important role in bacterial adherence and tissue tropism.