A Decade of EEG Theta/Beta Ratio Research in ADHD: A Meta-Analysis
A Decade of EEG Theta/Beta Ratio Research in ADHD: A Meta-Analysis
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DOI：
10.1177/1087054712460087
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发表时间：
2013-07-01
影响因子：
3
通讯作者：
Kraemer, Helena C.
中科院分区：
文献类型：
--
作者：
Arns, Martijn;Conners, C. Keith;Kraemer, Helena C.
目的：许多脑电图研究报告说，多动症的特征是theta/beta比率升高（TBR）。在这项研究中，我们对ADHD的TBR进行了荟萃分析。方法：从位置CZ开头的TBR数据分析了6-18岁的儿童/青少年，有或没有多动症。结果：确定了9项研究，总共有1253名儿童/青少年，有517个没有多动症。 6-13岁的孩子的盛大效应大小（ES）为0.75，而6-18岁的年龄为0.62。但是，异质性的测试仍然很大。因此，这些ESS具有误导性，并被认为是高估。事后分析发现多年来TBR的差异有所下降，解释说，非ADHD组的TBR增加。结论：过度TBR不能被认为是ADHD的可靠诊断度量，但是ADHD患者的大量亚组确实偏离了此措施，而TBR在此子组中具有预后价值，可以保证其用作预后措施，而不是诊断措施。
Objective: Many EEG studies have reported that ADHD is characterized by elevated Theta/Beta ratio (TBR). In this study we conducted a meta-analysis on the TBR in ADHD. Method: TBR data during Eyes Open from location Cz were analyzed from children/adolescents 6-18 years of age with and without ADHD. Results: Nine studies were identified with a total of 1253 children/adolescents with and 517 without ADHD. The grand-mean effect size (ES) for the 6-13 year-olds was 0.75 and for the 6-18 year-olds was 0.62. However the test for heterogeneity remained significant; therefore these ESs are misleading and considered an overestimation. Post-hoc analysis found a decreasing difference in TBR across years, explained by an increasing TBR for the non-ADHD groups. Conclusion: Excessive TBR cannot be considered a reliable diagnostic measure of ADHD, however a substantial sub-group of ADHD patients do deviate on this measure and TBR has prognostic value in this sub-group, warranting its use as a prognostic measure rather than a diagnostic measure.