The many roles of starburst amacrine cells
The many roles of starburst amacrine cells
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DOI：
10.1016/j.tins.2005.06.002
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发表时间：
2005-08-01
影响因子：
15.9
通讯作者：
Masland, RH
中科院分区：
文献类型：
--
作者：
Masland, RH
星爆无长突细胞释放两种经典的神经递质，ACh和GABA。在配对细胞记录的巡回演练中，郑等人。现在发现星暴细胞在发育早期是相互兴奋的，但在成年动物中是相互抑制的。这种变化是通过星暴细胞之间胆碱能和GABA能突触的重塑发生的。这一发现为视网膜活动的发育波提供了精确的机制基础。
Starburst amacrine cells release two classical neurotransmitters, ACh and GABA. In a tour de force of paired-cell recording, Zheng et al. now show that the starburst cells are mutually excitatory during early development but mutually inhibitory in adult animals. The change occurs by remodeling of both the cholinergic and the GABAergic synapses between starburst cells. The finding gives a precise mechanistic basis for the developmental waves of activity in the retina.