NEGATIVE STAINING IN DIAGNOSTIC VIROLOGY
NEGATIVE STAINING IN DIAGNOSTIC VIROLOGY
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DOI:
10.1016/0739-6260(91)90061-4
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发表时间:
1991-01-01
期刊:
影响因子:
--
通讯作者:
OZEL, M
中科院分区:
文献类型:
--
作者:
GELDERBLOM, HR;RENZ, H;OZEL, M
Negative staining has been quickly developed since the early 1960s to a world wide used technique for the direct visualization of viruses and macromolecules by electron microscopy (see Hayat and Miller, 1990). In particular, negative staining has become an indispensable method in the rapid diagnosis of viral diseases.In this article we describe briefly the history and development and discuss some methodological and diagnostic aspects of negative staining in virology.