Associations of the Oral Microbiota with Obesity and Menarche in Inner City Girls.
Associations of the Oral Microbiota with Obesity and Menarche in Inner City Girls.
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DOI：
10.21767/2572-5394.100068
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Wolff, Mary S
中科院分区：
文献类型：
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作者：
Mervish, Nancy A;Hu, Jianzhong;Wolff, Mary S
目的：口腔微生物群的改变与肥胖有关，可能是基于细菌介导的炎症过程。特定的细菌菌株与肥胖和牙周病有关。人们对儿童口腔微生物群知之甚少。了解口腔健康和儿童成长之间的关系有助于确定导致肥胖和相关疾病的可预防因素，包括与肥胖相关的月经初潮的开始。方法：在这项初步研究中，我们调查了纽约市市中心一家牙科诊所的25名7-15岁女孩(平均11.1岁)及其母亲的唾液微生物群。主要的观察指标是身体大小、是否有月经初潮和牙科实践。我们检验了微生物组丰富度、多样性和相对丰度与青春期和人口统计学因素以及口腔健康的关系。结果：根据所检测的所有物种的Shannon指数，女孩具有良好的牙齿健康和典型的丰富的口腔微生物组。年龄较大的女孩使用牙线的频率更高，年龄较小的女孩进行牙科检查的频率也更高。女孩的微生物群落丰富度与其母亲相似，但母亲的多样性大于女孩。在牙床出血、用牙线清洁和刷牙增加的母亲中，丰富度会降低。与正常体重的女孩相比，超重女孩的多样性更强，而丰富度更低。女孩是否达到月经初潮(黄杆菌属、放线杆菌属)、超重(巨型杆菌属、乳杆菌属、乳杆菌属)和牙龈炎(红藻门、双歧杆菌属、双歧杆菌属、双歧杆菌科)，某些细菌种类的丰度存在差异。结论：口腔微生物群中特定细菌的差异与身体大小和初潮有关。随着人们对与儿童肥胖的多因素病因相关的微生物组变异性的研究越来越感兴趣，唾液能够提供这种疾病和相关疾病的临床信息标记物。
OBJECTIVE: Alterations of the oral microbiome have been associated with obesity, possibly based on inflammatory processes mediated by bacteria. Specific bacterial strains have been associated with obesity and periodontal disease. Little is known about the oral microbiome in children. Understanding the relationship between oral health and childhood growth could help identify preventable factors contributing to obesity and related conditions, including onset of menarche which is associated with obesity.METHODS: In this pilot study, we investigated the saliva microbiome among 25 girls 7-15 years old (mean 11.1) and their mothers in an inner city dental clinic in New York City. The main outcome measures were body size, presence or absence of menarche and dental practices. We examined associations of microbiome richness, diversity, and relative abundance with pubertal and demographic factors and oral health.RESULTS: Girls had good dental health and a typical rich oral microbiome, based on the Shannon Index of all species detected. Older girls flossed more often and younger girls had more frequent dental check-ups. Microbiome richness among girls was similar to their mothers', but diversity was greater among mothers than girls. Richness was reduced among mothers with gum bleeding, flossing and increased teeth brushing. Overweight girls had greater diversity and less richness than normal weight girls. Certain bacterial species differed in abundance with respect to whether girls had reached menarche (Flavobacteria, Actinobacteria), overweight (Megasphaera, Lactorbacillales, Lactobacillus) and gingivitis in the girls (Scardovia, Bifidobacteriales, Gemellaceae).CONCLUSIONS: Differences found in specific bacteria in the oral microbiome were related to body size and menarche. With increasing interest on studying microbiome variability related to the multifactorial etiology of obesity in children, saliva is capable of providing clinically informative markers of this and related conditions.