The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
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DOI：
10.1002/jlb.67.4.508
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发表时间：
2000-04-01
影响因子：
5.5
通讯作者：
O'Neill, LAJ
中科院分区：
文献类型：
--
作者：
Bowie, A;O'Neill, LAJ
白细胞介素-1（IL-1）受体/Toll样受体（TLR）超家族是近年来发现的一组参与机体对损伤和感染反应的受体。该超家族由Toll/IL-1受体（TIR）结构域定义，其存在于家族成员的胞质区域中，并且基于与I型IL-1受体或果蝇Toll受体胞外结构域的同源性进一步细分为两组。前一组包括重要的Th 1细胞因子IL-18和T1/ST 2的受体，其可能在Th 2细胞功能中起作用。后一组包括六种哺乳动物TLR，包括TLR 2和TLR 4，其分别在很大程度上介导宿主对革兰氏阳性和革兰氏阴性细菌的应答。细菌产物是否是TLR的实际配体，或者它们是否通过尚未鉴定的模式识别受体产生配体，尚未确定。通过TIR结构域激活的信号传导途径触发下游激酶和转录因子如NF-κ B的激活，并涉及衔接蛋白MyD 88，其本身含有TIR结构域。
The interleukiu-1 (IL-1) receptor/Toll-like receptor (TLR) superfamily is a recently defined and expanding group of receptors that participate in host responses to injury and infection. The superfamily is defined by the Toll/IL-1 receptor (TIR) domain, which occurs in the cytosolic region of family members, and is further subdivided into two groups based on homology to either the Type I IL-1 receptor or Drosophila Toll receptor extracellular domain. The former group includes the receptor for the important Th1 cytokine IL-18, and T1/ST2, which may have a role in Th2 cell function, The latter group includes six mammalian TLRs, including TLR2 and TLR4, that largely mediate the host response to gram-positive and gram-negative bacteria, respectively. Whether bacterial products are actual ligands for TLRs, or whether they generate ligands via as yet unidentified pattern recognition receptors, has yet to he determined, Signaling pathways activated via the TIR domain trigger the activation of downstream kinases, and transcription factors such as NF-kappa B, and involve the adaptor protein MyD88, which itself contains a TIR domain.