A THEORY OF DOPAMINE FUNCTION AND ITS ROLE IN COGNITIVE DEFICITS IN SCHIZOPHRENIA
A THEORY OF DOPAMINE FUNCTION AND ITS ROLE IN COGNITIVE DEFICITS IN SCHIZOPHRENIA
复制标题
DOI：
10.1093/schbul/19.1.85
复制
发表时间：
1993-01-01
影响因子：
6.6
通讯作者：
SERVANSCHREIBER, D
中科院分区：
文献类型：
--
作者：
COHEN, JD;SERVANSCHREIBER, D
尽管对多巴胺（DA）功能的生物学和行为相关性进行了广泛的研究，但对DA可能产生精神分裂症中观察到的认知缺陷的机制知之甚少。神经网络模拟模型提供了一个框架，探索DA在生理水平上的影响如何影响行为。我们专注于研究结果表明，DA调制神经元的活动，通过增强神经元的能力，传输信号，减少噪声失真。这些现象可以通过增加网络各个单元的增益在模拟中捕捉到。当增益扩散增加时，这种网络的信号检测性能的改善与接受DA激动剂的人类受试者的性能的改善并行。此外，支持类似于前额叶皮层的记忆功能的网络模块中的增益降低导致与精神分裂症受试者相当的性能恶化。这种网络的表现，精神分裂症患者在一个新的变种的连续性能测试的预测进行了讨论。初步的数据是一致的预测和支持的帐户精神分裂症的认知缺陷的理论DA功能的模型建议。
In spite of extensive research on the biological and behavioral correlates of dopamine (DA) function, little is known about the mechanisms by which DA may produce the cognitive deficits observed in schizophrenia. Neural network simulation models offer a framework for exploring how DA effects at the physiological level may influence behavior. We focus on findings suggesting that DA modulates neuronal activity by enhancing the ability of neurons to transmit signals and reduce distortion by noise. These phenomena can be captured in simulations by increasing the gain of individual units of a network. When gain is increased diffusely, improvement in signal detection performance of such a network parallels the improvement in performance of human subjects receiving DA agonists. Furthermore, decreasing gain in a network module supporting a memory function analogous to that of prefrontal cortex results in deterioration of performance equivalent to that of schizophrenic subjects. A test of predictions made by such networks about the performance of schizophrenic patients in a new variant of the Continuous Performance Test is discussed. Preliminary data are consistent with predictions and support the account of schizophrenic cognitive deficits in terms of the theory of DA function suggested by the models.