Tone probe event-related potential differences during a face recognition task in prepubertal children and Turner Syndrome girls
Tone probe event-related potential differences during a face recognition task in prepubertal children and Turner Syndrome girls
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DOI：
10.1016/j.psyneuen.2004.03.004
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发表时间：
2004-11-01
影响因子：
3.7
通讯作者：
Shucard, DW
中科院分区：
文献类型：
--
作者：
Everhart, DE;Shucard, JL;Shucard, DW
激素已被证明在大脑发育和神经认知功能中发挥作用。特纳综合征（TS）提供了研究缺乏雌激素对神经认知发育的影响的机会。在这项研究中，事件相关电位（ERP）的差异进行了检查12 TS女孩，20青春期前的控制女孩，和20青春期前的控制男孩在面孔识别记忆任务。通过坦纳量表评分和激素测定确定青春期阶段。在参与者进行面孔识别记忆（FRM）任务的同时，从8个头皮部位记录了听觉探针刺激对的ERP。对于ERP的N2分量（以前与刺激信息，分类困难和注意力的评价相关），对照组男孩显示出更大的右半球与左半球的振幅，对照组女孩显示出更大的左半球与右半球的振幅，TS女孩没有振幅不对称。此外，对照组女孩的左半球N2振幅比对照组男孩和TS女孩大，右半球N2振幅比TS女孩大。结果表明，男孩在面部识别过程中更多的右半球激活，而对照组女孩则相反。相比之下，TS女孩没有显示不对称，表明在面部识别过程中左右半球的参与更加均匀。这些研究结果是一致的皮质组织的差异，面部识别记忆处理青春期前控制的男孩，女孩，TS女孩。他们还支持这样的观点，即认知功能的性别差异在青春期开始之前就存在，内源性性激素（例如，雌激素）在产前/围产期发育期间（即，对于TS女孩）可能会影响大脑组织，进而影响与面部识别相关的神经认知过程。(C)2004爱思唯尔有限公司保留所有权利。
Hormones have been shown to play a role in both cerebral development and neurocognitive function. Turner Syndrome (TS) provides the opportunity to study the effect of the lack of estrogen on neurocognitive development. In this study, event-related potential (ERP) differences were examined among 12 TS girls, 20 prepubertal control girls, and 20 prepubertal control boys during a face recognition memory task. Stage of puberty was determined by Tanner Scale rating and hormonal assay. ERPs to pairs of auditory probe stimuli were recorded from eight scalp sites while participants performed a faced recognition memory (FRM) task. For the N2 component of the ERP (which has previously been associated with evaluation of stimulus information, categorization difficulty, and attention), control boys displayed greater right versus left hemisphere amplitude, control girls displayed greater left versus right hemisphere amplitude, and there was no amplitude asymmetry for TS girls. Further, control girls had greater left hemisphere N2 amplitude than control boys and TS girls, and greater right hemisphere N2 amplitude than TS girls. The results suggest more right hemisphere activation during face recognition in boys, while the opposite pattern was present in control girls. In contrast, TS girls displayed no asymmetry, indicative of more uniform involvement of the left and right hemispheres during face recognition. These findings are consistent with differences in cortical organization related to face recognition memory processing among prepubertal control boys, girls, and TS girls. They also support the notion that sex differences in cognitive function are present prior to pubertal onset, and that tack of endogenous sex hormones (e.g., estrogen) during prenatal/perinatal development (i.e., for TS girls) may influence brain organization and, in turn, neurocognitive processes that relate to face recognition. (C) 2004 Elsevier Ltd. All rights reserved.