Substance use in a population-based clinic sample of people with first-episode psychosis
Substance use in a population-based clinic sample of people with first-episode psychosis
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DOI：
10.1192/bjp.bp.106.024448
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发表时间：
2007-06-01
影响因子：
10.5
通讯作者：
Jones, Peter B.
中科院分区：
文献类型：
--
作者：
Barnett, Jennifer H.;Werners, Ursula;Jones, Peter B.
背景物质的使用是牵连的原因和过程中的psychosis.Aims To discriminate物质和酒精的使用在流行病学上具有代表性的治疗样本的人经历了第一次精神病发作在南Cambridgeshire.Method当前和终身物质的使用记录为123个连续转介到一个专家早期干预服务。物质的使用进行了比较，一般人群患病率估计从英国犯罪SurveyResults物质使用的人与首发精神病是一般人群的两倍，男性比女性更常见。51%的患者（n=62）报告了大麻滥用，43%的患者（n=53）报告了酒精滥用。超过一半（n=68，55%）使用A类药物，38%（n=43）报告多种物质滥用。首次使用大麻，可卡因，摇头丸和安非他明的年龄显着相关的年龄在第一精神病symptoms.Conclusions物质滥用是存在于大多数人的首发精神病，并有重大影响的管理。首次使用药物的年龄与首次精神病症状之间的关联具有公共卫生意义。资金详情见鸣谢。
Background Substance use is implicated in the cause and course of psychosis.Aims To characterise substance and alcohol use in an epidemiologically representative treatment sample of people experiencing a first psychotic episode in south Cambridgeshire.Method Current and lifetime substance use was recorded for 123 consecutive referrals to a specialist early intervention service. Substance use was compared with general population prevalence estimates from the British Crime SurveyResults Substance use among people with first-episode psychosis was twice that of the general population and was more common in men than women. Cannabis abuse was reported in 51% of patients (n=62) and alcohol abuse in 43% (n=53). More than half (n=68, 55%) had used Class A drugs, and 38% (n=43) reported polysubstance abuse. Age at first use of cannabis, cocaine, ecstasy and amphetamine was significantly associated with age at first psychotic symptom.Conclusions Substance misuse is present in the majority of people with first-episode psychosis and has major implications for management. The association between age at first substance use and first psychotic symptoms has public health implications.Declaration of interest None. Funding detailed in Acknowledgements.