The shape of things to come: Structural and synthetic studies of taxol and related compounds
The shape of things to come: Structural and synthetic studies of taxol and related compounds
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DOI：
10.1016/j.phytochem.2006.11.009
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发表时间：
2007-07-01
期刊：
影响因子：
3.8
通讯作者：
Kingston, David G. I.
中科院分区：
文献类型：
--
作者：
Kingston, David G. I.
综述了紫杉醇作为抗癌药物的发展历史，并讨论了红豆杉属植物化学和紫杉醇药物化学的某些方面。紫杉醇微管蛋白相互作用的性质，然后描述，重点研究，导致发现和实验证明的T-紫杉醇构象的微管蛋白结合构象的紫杉醇。还简要介绍了这种构象对未来药物开发的影响。(c)2006爱思唯尔有限公司保留所有权利。
The history of the development of Taxol (R) (paclitaxel) as an anticancer drug is reviewed, and some aspects of the phytochemistry of Taxus species and of the medicinal chemistry of taxol are discussed. The nature of the taxol-tubulin interaction is then described, with an emphasis on studies that led to the discovery and experimental proof of the T-taxol conformation as the tubulin-binding conformation of taxol. The implications of this conformation for future drug development are also briefly covered. (c) 2006 Elsevier Ltd. All rights reserved.