A comparative study of combined treatment with a collagen membrane and enamel matrix proteins for the regeneration of intraosseous defects.
A comparative study of combined treatment with a collagen membrane and enamel matrix proteins for the regeneration of intraosseous defects.
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胶原膜和牙釉质基质蛋白联合治疗骨内缺损再生的比较研究。
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
Eiko Mitarai
中科院分区：
文献类型：
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作者：
M. Minabe;T. Kodama;T. Kogou;K. Takeuchi;H. Fushimi;T. Sugiyama;Eiko Mitarai
最近的临床研究表明，使用牙釉质基质蛋白（Emdogain； EMD）进行牙周再生治疗有望达到与引导组织再生（GTR）相同的治疗效果。然而，关于两种治疗联合效果的报道有限，临床意义尚不明确。本研究通过比较胶原膜EMD和GTR联合治疗骨内缺损与GTR单药治疗和EMD单药治疗的临床效果。包括61例69个骨内缺陷。在6个月和1年通过评估探探深度减少、探探附着增加和x线片骨增加来评估治疗效果。三个治疗组术前软组织测量和缺损特征之间无统计学差异。结果显示，在两个评估时间，三个治疗组在探探深度减少、探探附着增加或x线片骨增加方面没有显著差异。使用可吸收膜治疗骨内缺损的GTR与EMD联合使用与单独治疗相比，并没有提高治疗效果。
Recent clinical study shows that periodontal regeneration therapy using enamel matrix proteins (Emdogain; EMD) is expected to have the same therapeutic effect as guided tissue regeneration (GTR). However, reports on the combined effect of both therapies are limited, and the clinical significance is not definite. In this study, clinical effects were studied by comparing a combination of EMD and GTR using a collagen membrane for intrabony defects with GTR monotherapy and EMD monotherapy. Sixty-one patients with 69 intrabony defects were included. Efficacy of treatment was evaluated at 6 months and 1 year by assessment of reduction of probing depth, probing attachment gain, and radiographic bone gain. There were no statistically significant differences between presurgical soft tissue measurements and defect characteristics for the three treatment groups. The results showed no significant differences in reduction of probing depth, probing attachment gain, or radiographic bone gain between the three treatment groups at both evaluation times. The combination of GTR using a resorbable membrane for intrabony defects and EMD did not enhance the therapeutic effect compared with each monotherapy.