METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages.
METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages.
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DOI：
10.1016/j.clim.2014.11.006
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Zlotnik A
中科院分区：
文献类型：
--
作者：
Ushach I;Burkhardt AM;Martinez C;Hevezi PA;Gerber PA;Buhren BA;Schrumpf H;Valle-Rios R;Vazquez MI;Homey B;Zlotnik A
Cytokines are involved in many functions of the immune system including initiating, amplifying and resolving immune responses. Through bioinformatics analyses of a comprehensive database of gene expression (BIGE: Body Index of Gene Expression) we observed that a small secreted protein encoded by a poorly characterized gene called meteorin-like (METRNL), is highly expressed in mucosal tissues, skin and activated macrophages. Further studies indicate that Metrnl is produced by Alternatively Activated Macrophages (AAM) and M-CSF cultured bone marrow macrophages (M2-like macrophages). In the skin, METRNL is expressed by resting fibroblasts and IFNγ-treated keratinocytes. A screen of human skin-associated diseases showed significant over-expression of METRNL in psoriasis, prurigo nodularis, actinic keratosis and atopic dermatitis. METRNL is also up-regulated in synovial membranes of human rheumatoid arthritis. Taken together, these results indicate that Metrnl represents a novel cytokine, which is likely involved in both innate and acquired immune responses.
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影响因子：
3.7
作者：
Gerber PA;Hevezi P;Buhren BA;Martinez C;Schrumpf H;Gasis M;Grether-Beck S;Krutmann J;Homey B;Zlotnik A
通讯作者：
Zlotnik A
影响因子：
3
作者：
DjemadjiOudjiel, N;Goerdt, S;Orfanos, CE
通讯作者：
Orfanos, CE
影响因子：
4.8
作者：
Lee, J;Hever, A;Hevezi, P
通讯作者：
Hevezi, P
影响因子：
4
作者：
Lee, Hye Shin;Han, Jiyeon;Kim, Kyu-Won
通讯作者：
Kim, Kyu-Won
影响因子：
4.4
作者：
Lacey, Derek C.;Achuthan, Adrian;Hamilton, John A.
通讯作者：
Hamilton, John A.