ISSLS prize winner: The innervation of the intervertebral disc: A quantitative analysis
ISSLS prize winner: The innervation of the intervertebral disc: A quantitative analysis
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DOI：
10.1097/01.brs.0000096942.29660.b1
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发表时间：
2003-12-01
期刊：
影响因子：
3
通讯作者：
Fraser, R
中科院分区：
文献类型：
--
作者：
Fagan, A;Moore, R;Fraser, R
目标。本文首次对腰椎间盘的神经支配进行了定量分析。采用羊模型对整个运动段进行评估。使用了四根羊刺。1例采用PGP 9.5免疫荧光法，3例采用PGP 9.5免疫过氧化物酶组织化学法。对终板和环的神经支配密度进行计数，并进行比较。终板和环神经支配密度无显著差异。终板神经支配集中在靠近核的中央。神经支配最丰富的区域是环周结缔组织。腰椎间盘神经支配薄弱。这主要集中在环周结缔组织和中央终板。虽然受体阈值与伤害功能的关系比神经支配密度更密切，但这些发现对任何椎间盘源性疼痛的治疗都具有重要意义。
Objective. The first quantitative analysis of the innervation of the lumbar intervertebral disc is presented.Methods. A sheep model was used allowing evaluation of the whole motion segment. Four sheep spines were used. One was processed for PGP 9.5 immunofluorescence and three were processed for PGP 9.5 immunoperoxidase histochemistry. A count was made of the densities of innervation of the endplate and anulus, and these were compared.Results. There is no significant difference between endplate and anulus innervation densities. The endplate innervation is concentrated centrally adjoining the nucleus. The richest area of innervation is in the perianular connective tissue.Discussion. The lumbar intervertebral disc has a meager innervation. This is concentrated in the perianular connective tissue and the central endplate. Although receptor threshold is more closely related to nociceptive function than innervation density, these findings have important implications for any treatment of discogenic pain.