Ocular abnormalities occurring with vitiligo.
Ocular abnormalities occurring with vitiligo.
复制标题
白癜风引起的眼部异常。
DOI：
10.1016/s0161-6420(79)35413-6
复制
发表时间：
1979
期刊：
影响因子：
13.7
通讯作者：
Aaron B. Lerner
中科院分区：
文献类型：
--
作者：
Daniel M. Albert;James J. Nordlund;Aaron B. Lerner
对112例白癜风患者进行了眼部异常检查。在44例患者中观察到临床上表现为涉及脉络膜和视网膜色素上皮的色素脱失和相关色素增生的离散区域，在9例患者中观察到活动性葡萄膜炎。观察到的变化表明，包括原田病和Vogt-Koyanagi综合征在内的疾病谱可能比以前认识到的更广泛。患有这些综合征的患者可能是白癜风和葡萄膜炎症的最严重的例子。12例患者出现夜盲症状，其中2例患者有视网膜色素变性家族史，这可能意味着视网膜色素上皮细胞可能出现功能障碍。色素上皮疾病的进一步证据是在这些患者中异常突出的脉络膜模式的高发病率。
One hundred twelve patients with vitiligo were examined for ocular abnormalities. Discrete areas of depigmentation with associated pigment hyperplasia clinically appearing to involve the choroid and retinal pigment epithelium were observed in 44 patients, and active uveitis was seen in nine patients. The changes observed suggest that the spectrum of diseases that includes Harada's disease and the Vogt-Koyanagi syndrome may be broader than previously appreciated. Patients with these syndromes may represent the most severe examples of vitiligo and uveal inflammation. The occurrence of symptoms of night blindness in 12 patients and a family history of retinitis pigmentosa in two of these may signify a possible malfunction of the retinal pigment epithelium. Further evidence for a pigment epithelium disorder is suggested by the high incidence of an unusually prominent choroidal pattern in these patients.