Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy.
Assessment of blood supply in superficial tissue by polarization-gated elastic light-scattering spectroscopy.
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DOI：
10.1364/ao.45.000335
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发表时间：
2006-01
期刊：
影响因子：
1.9
通讯作者：
Michael P. Siegel;Young L. Kim;H. Roy;R. Wali;V. Backman
中科院分区：
文献类型：
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作者：
Michael P. Siegel;Young L. Kim;H. Roy;R. Wali;V. Backman
我们报告的可行性监测血红蛋白氧饱和度和血红蛋白浓度在组织的表层使用偏振选通弹性光散射光谱。我们详细介绍了我们的分析技术，我们的分析的实验验证，并检测早期增加血液供应的结肠组织在人类结肠腺瘤患者的浅层，以及在结肠癌的动物模型。据我们所知，这项研究代表了第一个证据，偏振门控可以用作光谱工具，以量化血红蛋白浓度以及氧饱和度在最上层的组织层。
We report the feasibility of monitoring both hemoglobin oxygen saturation and hemoglobin concentration in the superficial layer of tissue using polarization-gated elastic light-scattering spectroscopy. We detail our analysis technique, the experimental validation of our analysis, and the detection of an early increase in blood supply to the superficial layer of colon tissue in human patients with colonic adenomas as well as in an animal model of colon carcinogenesis. To the best of our knowledge, this study represents the first evidence that polarization gating can be used as a spectroscopic tool to quantify hemoglobin concentration as well as oxygen saturation in the uppermost tissue layer.