A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice
A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice
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DOI：
10.1016/j.febslet.2006.04.065
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发表时间：
2006-05-29
期刊：
影响因子：
3.5
通讯作者：
Baba, Tadashi
中科院分区：
文献类型：
--
作者：
Iwase, Shigeki;Shono, Naomi;Baba, Tadashi
BHC 80是BRAF-HDAC复合物（BHC）的一个组成部分，参与非神经元细胞中神经元特异性基因的转录抑制。然而，BHC 80存在于神经元和非神经元细胞中。为了探索BHC 80在体内的生理重要性，以及BHC 80对神经元特异性基因抑制的确切机制，我们产生了缺乏BHC 80的突变小鼠。Bhc 80的缺失导致新生儿在没有充分吮吸母亲母乳的情况下死亡。虽然Bhc 80缺陷小鼠在神经元和非神经元组织中没有表现出发育缺陷，但Bhc 80对于新生幼崽的存活是不可或缺的。(c)2006年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
BHC80 is a component of BRAF-HDAC complex (BHC) involved in transcriptional repression of neuron-specific genes in non-neuronal cells. However, BHC80 is present in both neuronal and non-neuronal cells. To explore the physiological importance of BHC80 in vivo, and the precise mechanism underlying neuron-specific gene repression by BHC80, we have produced mutant mice lacking Bhc80. The loss of Bhc80 resulted in neonatal lethality without sucking mother's breast milk sufficiently. Although Bhc80-deficient mice showed no developmental defect in the neuronal and non-neuronal tissues, Bhc80 is indispensable for the survival of neonatal pups. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.