A Highly Efficient Copper-Catalyzed Three-Component Synthesis of 4-Aminoquinazolines
A Highly Efficient Copper-Catalyzed Three-Component Synthesis of 4-Aminoquinazolines
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DOI：
10.1055/s-0036-1588727
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Dongyin Chen
中科院分区：
文献类型：
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作者：
Lei Yang;Honghua Luo;Yan Sun;Zhenyu Shi;Kaidong Ni;Fei Li;Dongyin Chen
A highly efficient copper-catalyzed one-pot protocol is developed for the synthesis of 4-aminoquinazolines from easily available 2-iodo- or 2-bromobenzimidamides, aldehydes, and sodium azide. This one-pot approach proceeds via consecutive copper-catalyzed SNAr substitution, reduction, cyclization, oxidation and tautomerization. The corresponding target products (26 examples) are obtained in 50–90% yield.
