Coexistence of salusin and vasopressin in the rat hypothalamo-hypophyseal system
Coexistence of salusin and vasopressin in the rat hypothalamo-hypophyseal system
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DOI：
10.1016/j.neulet.2005.05.061
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发表时间：
2005-09-09
影响因子：
2.5
通讯作者：
Shioda, S
中科院分区：
文献类型：
--
作者：
Takenoya, AF;Hori, T;Shioda, S
Salusins是两种新发现的TOR相关肽，分别由28个和20个氨基酸组成，分别命名为salusin-alpha和salusin-beta。应用免疫组织化学技术，salusin样免疫反应阳性细胞在大鼠下丘脑-神经垂体束和免疫阳性细胞分布在视交叉上核，视上核和室旁核。在室旁核，salusin样免疫反应观察到小细胞和大细胞神经元。在正中隆起和垂体后叶内层可见大量salusin阳性神经纤维及其终末。salusin阳性染色在视交叉上核和正中隆起外层的纤维和终末较弱。进行双重免疫染色以确定salusin是否与下丘脑中的加压素或催产素共存。大多数的salusin样免疫反应性被检测到的加压素，但不是在催产素在这些核中的神经元。salusin与加压素共存的功能意义进行了讨论，包括salusin参与血压调节的可能性。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Salusins are two newly discovered TOR-related peptides consisting of 28 and 20 amino acids and designated salusin-alpha and salusin-beta, respectively. Using immunohistochemistry techniques, salusin-like immunoreactivity was detected in the rat hypothalamo-neurohypophyseal tract and immunopositive cells were distributed in the suprachiasmatic, supraoptic and paraventricular nucleus. In the paraventricular nucleus, salusin-like immunoreactivity was observed both in parvocellular and magnocellular neurons. Many salusin-positive nerve fibers and their terminals were identified in the internal layer of the median eminence and posterior pituitary. Less intense salusin-positive staining of fibers and terminals was found in the suprachiasmatic nucleus and external layer of the median eminence. Dual immunostaining was performed to determine if salusin coexisted with vasopressin or oxytocin in the hypothalamus. Most of the salusin-like immunoreactivity was detected in vasopressin- but not in oxytocin-containing neurons in these nuclei. The functional significance of the coexistence of salusin with vasopressin is discussed, including the possibility that salusin participates in the regulation of blood pressure. (c) 2005 Elsevier Ireland Ltd. All rights reserved.