MECHANISMS UNDERLYING SATIATION OF FEEDING-BEHAVIOR OF THE MOLLUSK APLYSIA
MECHANISMS UNDERLYING SATIATION OF FEEDING-BEHAVIOR OF THE MOLLUSK APLYSIA
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DOI：
10.1016/s0163-1047(87)90836-3
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发表时间：
1987-09-01
期刊：
影响因子：
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通讯作者：
KUPFERMANN, I
中科院分区：
文献类型：
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作者：
KUSLANSKY, B;WEISS, KR;KUPFERMANN, I
动物吃了大量的无营养物质几乎饱足，但吃少量的海藻却不会饱足。这表明饱食不是由位于前部的“热点”的化学刺激触发的。放置在动物肠道中的气球的膨胀导致饱食，如进食行为的许多不同参数所反映的。相对短暂的通货膨胀的抑制作用是迅速和完全可逆的，尽管反复的通货膨胀和通货紧缩似乎产生缓慢可逆或不可逆的影响。在肠道膨胀过程中喂养变化的参数与缓慢喂食单个食物的正常动物的参数相当。使动物吃饱所需的充气量是充气速率的函数。切断食管神经导致使动物吃饱所需的体积显著增加，但尽管如此，它们最终停止进食，并且通常不显示肠爆裂。证据表明，在神经切断的动物中最终发生的饱食，至少部分是由于长时间的感觉刺激后的摄食抑制。这些数据表明，对于快速消耗的膳食，饱食的结果主要是由于食管神经传递的扩张相关的肠道信号，而对于非常缓慢消耗的膳食，前一个因素与感官刺激相关的过程相互作用，如受体适应。目前的结果表明，气球扩张可以作为一个合理的刺激，在实验中的简化准备，其中神经系统可以研究。
Animals filled almost to satiation by nonnutritive bulk do not satiate when they ingest a small amount of seaweed. This suggests that satiation is not triggered by chemostimulation of an anteriorly located "hot spot". Inflation of a balloon placed in the gut of the animal results in satiation as reflected in a number of different parameters of feeding behavior. The suppressive effect of a relatively brief inflation is rapidly and fully reversible, although repeated inflation and deflation appeared to produce slowly reversible or irreversible effects. The parameters of the changes in feeding during gut inflation are comparable to those of normal animals that are slowly fed individual pieces of food. The inflation volume needed to satiate the animal is a function of the rate of inflation.sbd.more rapid inflations requiring larger volumes. Cutting of the esophageal nerves results in a significant increase in the volume needed to satiate the animals, but nevertheless they eventually cease feeding and generally do not show a burst gut. The evidence indicates that the satiation that eventually occurs in nerve-sectioned animals, at least in part, is due to depression of feeding following very prolonged sensory stimulation. The data suggest that for a rapidly consumed meal, satiation results primarily due to distension-related gut signals conveyed by the esophageal nerves, whereas for very slowly consumed meals, the former factor interacts with a process associated with sensory stimulation, such as receptor adaptation. The current results indicate that balloon distension can serve as a reasonable stimulus in experiments in simplified preparations in which the nervous system can be studied.