Radiotherapy and wound healing.
Radiotherapy and wound healing.
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DOI：
10.1111/j.1742-4801.2005.00079.x
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发表时间：
2005-06-01
影响因子：
3.1
通讯作者：
Goodacre, Timothy E E
中科院分区：
文献类型：
--
作者：
Dormand, Emma-Louise;Banwell, Paul E;Goodacre, Timothy E E
放射治疗是治疗癌症的一种宝贵武器。然而，辐射的即时和长期有害影响可能对局部组织产生重大影响。放射损伤组织中的伤口愈合问题构成了在需要放射治疗或过去已经进行过放射治疗的患者的管理期间经常被忽视的主要问题。伤口愈合不良可能导致慢性溃疡、疼痛、继发感染和心理困扰，并影响普通手术或重建手术的结果。我们讨论了放射治疗后伤口愈合不良的病理生理学，放射损伤组织的具体问题和改善受照射组织伤口愈合的潜在治疗方法。
Radiotherapy is an invaluable weapon when treating cancer. However, the deleterious effects of radiation, both immediate and long-term, may have a significant effect on local tissues. Problematic wound healing in radiation-damaged tissue constitutes a major problem that is frequently overlooked during the management of patients who require radiotherapy, or have had radiotherapy in the past. Poor wound healing may lead to chronic ulceration, pain, secondary infection and psychological distress and compromise the outcome of general or reconstructive surgery. We discuss the pathophysiology of poor wound healing following radiotherapy, specific problems for radiation-damaged tissue and potential treatments to improve wound healing of irradiated tissues.