Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E
Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E
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DOI：
10.1016/s0197-4580(01)00223-8
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发表时间：
2001-07-01
影响因子：
4.2
通讯作者：
Stern, Y
中科院分区：
文献类型：
--
作者：
Mayeux, R;Small, SA;Stern, Y
表达人 APOE-epsilon4 的转基因小鼠会出现年龄依赖性记忆衰退，但没有阿尔茨海默病 (AD) 的病理特征。这表明 APOE 在正常衰老过程中维持记忆，但平行的人类研究是有限的，因为记忆的纵向研究通常不排除患有 AD 或“可疑”AD (QD) 的患者。目前的研究考察了 APOE 对无痴呆老年人认知功能的影响。我们假设，与其他 APOE 等位基因相比，即使在健康老年人中，携带 APOE-epsilon4 的人记忆力下降也会更大。神经心理学测试的结果。通过因子分析将其分为记忆、语言和视觉空间/认知功能领域，并使用广义估计方程在七年的时间内以三个时间间隔对 563 名没有 AD 或 QD 的健康老年人进行检查。 Memory performance declined over time.而视觉空间/认知和语言因素的得分没有变化。年龄的增加与较低的分数相关，受教育程度越高，每个时间间隔的所有因素得分越高，没有 APOE 等位基因与任何时间间隔的特定认知因素的表现相关，但 APOE-epsilon4 等位基因的存在与随访期间记忆因素的更快下降相关。这种效应在受过不到 10 年正规教育的人中最为明显。 APOE-epsilon4 与语言或视觉空间/认知因素之间不存在类似的时间依赖性关系。表达 APOE-epsilon4 的转基因小鼠和没有 AD 或 QD 的老年人表现出记忆能力随着时间的推移而下降。这些观察结果为衰老过程中 APOE 对记忆的特异性影响提供了证据。 (C) 2001 Elsevier Science Inc. 保留所有权利。
Transgenic mice expressing human APOE-epsilon4 develop an age-dependent decline in memory without pathological features of Alzheimer's disease (AD). This implicates APOE in the maintenance of memory during normal senescence, but parallel human studies are limited because longitudinal investigations of memory usually do not exclude patients with AD or "questionable" AD (QD). The current study examined the effect of APOE on cognitive function over rime in elderly without dementia. We hypothesised that, compared to other APOE alleles memory decline even in healthy elderly would be greater among those with an APOE-epsilon4.The results of neuropsychological tests. grouped into domains of memory, language and visuospatial/cognitive function by factor analysis, were examined at three intervals over a seven-year period in 563 healthy elderly without AD or QD using generalized estimating equations. Memory performance declined over time. while scores on the visuospatial/cognitive and language factors did not change. Increased age was associated with lower scores, and higher education with higher scores on all factors at each interval, No APOE allele was associated with performance on a specific cognitive factor at any interval, but the presence of an APOE-epsilon4 allele was associated with a more rapid decline in the memory factor over the follow-up period. The effect was most pronounced among individuals with less than 10 years of formal education. There was no similar time-dependent relationship between APOE-epsilon4 and the language or visuospatial/cognitive factors.Transgenic mice and elderly humans without AD or QD expressing APOE-epsilon4 show a decline in memory performance over time. These observations provide evidence for an APOE-specific effect on memory during senescence. (C) 2001 Elsevier Science Inc. All rights reserved.