Postpartum thyroid dysfunction in Bangkok: a geographical variation in the prevalence.
Postpartum thyroid dysfunction in Bangkok: a geographical variation in the prevalence.
复制标题
曼谷产后甲状腺功能障碍：患病率的地理差异。
DOI：
10.1530/acta.0.1220283
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Winit Puapradit
中科院分区：
文献类型：
--
作者：
R. Rajatanavin;L. Chailurkit;Kanokporn Tirarungsikul;W. Chalayondeja;U. Jittivanich;Winit Puapradit
为了确定泰国产后妇女甲状腺功能障碍的患病率，我们评估了812名产后1.5个月的泰国妇女的甲状腺功能和甲状腺自身抗体。在产后3.5个月，570名以前没有甲状腺异常的妇女返回进行第二组甲状腺功能测试。甲状腺功能不全的患病率为1.1%，低于其他国家的报告。各种类型的产后甲状腺功能障碍，即短暂性甲状腺毒症，其次是短暂性甲状腺功能减退症，短暂性甲状腺毒症或甲状腺功能减退症单独发生或永久性甲状腺功能减退症。9例甲状腺功能异常患者中8例有甲状腺自身抗体。4例行甲状腺细针穿刺活检，均为淋巴细胞性甲状腺炎。尽管曼谷是一个碘过量的地区，碘摄入量相对低于其他地区，在那里产后甲状腺功能障碍的患病率要高得多。产后甲状腺功能障碍的地理患病率差异可能是由于不同种族背景的免疫遗传异质性、环境碘摄入量和其他未知环境因素的相互作用。
To determine the prevalence of thyroid dysfunction in Thai postpartum women, we evaluated thyroid function and thyroid autoantibodies in 812 consecutive unselected women at 1.5 months post partum. At 3.5 months post partum 570 women without previous thyroid abnormality returned for a second set of thyroid function test. The prevalence of thyroid dysfunction was 1.1%, which was less than that reported from other countries. Various types of postpartum thyroid dysfunction, namely, transient thyrotoxicosis followed by transient hypothyroidism, transient thyrotoxicosis or hypothyroidism occurring alone or permanent hypothyroidism were encountered. Eight out of 9 patients with thyroid dysfunction had thyroid autoantibodies. Fine needle aspiration biopsy of the thyroid was done in 4 patients and all showed lymphocytic thyroiditis. Even though Bangkok is an iodine surfeit area, iodine intake is relatively lower than in other areas where the prevalence of postpartum thyroid dysfunction is much higher. The discrepancy in geographic prevalence of postpartum thyroid dysfunction may result from the interaction of immunogenetic heterogeneity of different ethnic background, environmental iodine intake, and other unidentified environmental factors.