CONCENTRATIONS OF STRIATAL CATECHOLAMINES IN RATS GIVEN MANGANESE CHLORIDE THROUGH DRINKING-WATER
CONCENTRATIONS OF STRIATAL CATECHOLAMINES IN RATS GIVEN MANGANESE CHLORIDE THROUGH DRINKING-WATER
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DOI：
10.1111/j.1471-4159.1981.tb01642.x
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发表时间：
1981-01-01
影响因子：
4.7
通讯作者：
SHUKLA, GS
中科院分区：
文献类型：
--
作者：
CHANDRA, SV;SHUKLA, GS
雄性白化病大鼠通过饮用含MnCl 2·4 H2O（1 mg/ml）的水溶液暴露于Mn。在360天的不同时间间隔内，测定纹状体中儿茶酚胺、高香草酸（HVA）、锰的含量和单胺氧化酶（MAO）的活性。同时测定纹状体和血清中酪氨酸含量。锰处理引起纹状体多巴胺（DA）、去甲肾上腺素（NE）、HVA和酪氨酸含量的初步增加。随后是浓度几乎正常的时期（Mn给药后120-240天的DA，180和240天的NE和240天的HVA）。此后，这些底物的含量在处理的300和360天显著下降。这些变化与该区域的Mn浓度无关，该区域的Mn浓度逐渐增加至240天，此后保持恒定，直到实验结束。锰引起的纹状体的儿茶酚胺含量的顺序变化的基本生化机制进行了讨论有关的发展[人类]精神和神经阶段的锰中毒。
Male albino rats were exposed to Mn through a drinking solution containing MnCl2.cntdot.4H2O (1 mg/ml) in water. The contents of catecholamines, homovanillic acid [HVA], Mn and the activity of monoamine oxidase (MAO) were measured in the corpus striatum at different time intervals up to 360 days. The contents of tyrosine in the corpus striatum and serum were also estimated. Mn treatment produced an initial increase in the contents of dopamine (DA), norepinephrine (NE), HVA and tyrosine in the corpus striatum. This was followed by a period when concentrations were almost normal (DA at 120-240 days, NE at 180 and 240 days and HVA at 240 days after Mn administration). Thereafter the contents of these substrates declined significantly at 300 and 360 days of treatment. These alterations were not correlated with the concentration of Mn in this region, which gradually increased up to 240 days, and thereafter remained constant until the termination of the experiment. The underlying biochemical mechanisms of Mn-induced sequential changes in the striatal contents of catecholamines are discussed in relation to the development of [human] psychiatric and neurological phases of Mn poisoning.