Neuroblastoma. Evaluation of the treatment of 90 children.
Neuroblastoma. Evaluation of the treatment of 90 children.
复制标题
成神经细胞瘤。
作者：
C. Priebe;H. Clatworthy
神经母细胞瘤是儿童期最常见的软组织恶性肿瘤。哥伦布儿童医院在过去 21 年中记录了 92 例病例。我们回顾性地研究了这些接受不同管理的患者，并在此过程中试图回答有关该疾病治疗的几个问题。患者需要多长时间的无肿瘤生存才能被视为治愈？化疗，尤其是环磷酰胺（Cytoxan）是否可以延长生存期或提高治愈率？重复手术是否可以提高持续性或复发性肿瘤的治愈率？辐照治疗对治愈率有何贡献？最后，未来几年神经母细胞瘤儿童的预计治疗方法应该是什么？神经母细胞瘤的治疗经历了四个时代。 1920年代初期的第一个或“无所作为”时代利用了这种特殊的恶性肿瘤可能会自发消退的事实
NEUROBLASTOMA is the most commonly encountered soft tissue malignancy in childhood. At the Columbus Children's Hospital, 92 cases have been recorded during the past 21 years. We have studied these variously managed patients retrospectively and, in doing so, we have attempted to answer several questions regarding the treatment of this disease. What length of tumor free survival is necessary before a patient may be considered cured? Has chemotherapy, particularly with cyclophosphamide (Cytoxan), prolonged survival or increased the cure rate? Do repeated operations improve curability for persistent or recurrent tumor? What is the contribution of irradiation treatment to curability rate? Finally, what should be the projected method of management of children with neuroblastoma over the next few years? There have been four eras in the management of neuroblastoma. The first or "do nothing" era in the early 1920's took advantage of the fact that this particular malignant tumor may spontaneously regress