Melatonin attenuates the skin sympathetic nerve response to mental stress.
Melatonin attenuates the skin sympathetic nerve response to mental stress.
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褪黑激素减弱皮肤交感神经对精神压力的反应。
DOI：
10.1152/ajpheart.00470.2013
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ray,ChesterA
中科院分区：
文献类型：
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作者：
Muller,MatthewD;Sauder,CharityL;Ray,ChesterA
褪黑激素减弱肌肉交感神经对交感神经兴奋性刺激的反应，但褪黑激素是否类似地减弱皮肤交感神经活动（SSNA）的反射变化尚不清楚。在这项双盲、安慰剂对照、交叉研究中，我们检验了褪黑激素（3 mg）会减弱SSNA对精神压力（心算）的反应的假设。12名健康受试者在两天内接受了实验测试。在摄入褪黑激素（3 mg）或安慰剂之前和之后45分钟，分别进行3分钟的精神压力测试。皮肤温度保持在34°C。在褪黑激素之前和之后，测定了SSNA（腓神经）、平均动脉压和心率（HR）对精神应激的反射增加。褪黑激素降低静息时的HR（术前，66 ± 3次/分钟;术后，62 ± 3次/分钟，P= 0.046）和SSNA（术前，14，282 ± 3，706个任意单位;术后，9，571 ± 2，609个任意单位，P= 0.034）。在精神应激反应中，摄入褪黑激素后，SSNA增加显著减弱（第2分钟，114 ± 30 vs. 74 ± 14%;第3分钟，111 ± 29 vs. 54 ± 12%，均P < 0.05）。在褪黑素治疗后第3分钟，平均动脉压对精神压力的增加变得迟钝（20 ± 2 vs. 17 ± 2 mmHg，P= 0.032），在第1分钟，HR增加变得迟钝（33 ± 3 vs. 29 ± 3 beats/min，P= 0.034）。总之，外源性褪黑激素减弱了SSNA对精神应激的反应。
Melatonin attenuates muscle sympathetic nerve responses to sympathoexcitatory stimuli, but it is unknown whether melatonin similarly attenuates reflex changes in skin sympathetic nerve activity (SSNA). In this double-blind, placebo-controlled, crossover study, we tested the hypothesis that melatonin (3 mg) would attenuate the SSNA response to mental stress (mental arithmetic). Twelve healthy subjects underwent experimental testing on two separate days. Three minutes of mental stress occurred before and 45 min after ingestion of melatonin (3 mg) or placebo. Skin temperature was maintained at 34°C. Reflex increases in SSNA (peroneal nerve), mean arterial pressure, and heart rate (HR) to mental stress before and after melatonin were determined. Melatonin lowered HR (pre, 66 ± 3 beats/min; and post, 62 ± 3 beats/min,P= 0.046) and SSNA (pre, 14,282 ± 3,706 arbitrary units; and post, 9,571 ± 2,609 arbitrary units,P= 0.034) at rest. In response to mental stress, SSNA increases were significantly attenuated following melatonin ingestion (second minute, 114 ± 30 vs. 74 ± 14%; and third minute, 111 ± 29 vs. 54 ± 12%, bothP< 0.05). The mean arterial pressure increase to mental stress was blunted in the third minute (20 ± 2 vs. 17 ± 2 mmHg,P= 0.032), and the HR increase was blunted in the first minute (33 ± 3 vs. 29 ± 3 beats/min,P= 0.034) after melatonin. In summary, exogenous melatonin attenuates the SSNA response to mental stress.