Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis.
Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis.
复制标题
DOI：
10.1016/j.dld.2010.01.008
复制
发表时间：
2010-04
影响因子：
4.5
通讯作者：
Gaudio, Eugenio
中科院分区：
文献类型：
--
作者：
Glaser, Shannon S.;Onori, Paolo;Wise, Candace;Yang, Fuguan;Marzioni, Marco;Alvaro, Domenico;Franchitto, Antonio;Mancinelli, Romina;Alpini, Gianfranco;Munshi, Md. Kamruzzaman;Gaudio, Eugenio
胆管上皮细胞（即胆管细胞）排列在肝内胆管上皮上，是许多人类胆汁淤积性肝病（称为胆管病）的靶细胞。胆管细胞增殖和死亡几乎存在于所有人类胆管病中。最近的许多研究为胆汁淤积性肝病发病过程中调节胆管细胞增殖和功能的关键机制提供了见解。在我们的综述中，我们总结了过去 3 年中最重要的最新研究，重点是在肝外胆管结扎动物模型中进行的研究。在综述的第一部分，我们提供了胆管系统的相关背景。然后，我们对胆管结扎胆汁淤积动物模型中调节胆道增殖的因素进行一般性讨论。进一步表征调节胆管细胞增殖和功能的因素将有助于阐明调节人类胆道疾病发病机制的机制，并为这些破坏性疾病设计新的治疗方法。
Bile duct epithelial cells (i.e., cholangiocytes), which line the intrahepatic biliary epithelium, are the target cells in a number of human cholestatic liver diseases (termed cholangiopathies). Cholangiocyte proliferation and death is present in virtually all human cholangiopathies. A number of recent studies have provided insights into the key mechanisms that regulate the proliferation and function of cholangiocytes during the pathogenesis of cholestatic liver diseases. In our review, we have summarised the most important of these recent studies over the past 3 years with a focus on those performed in the animal model of extrahepatic bile duct ligation. In the first part of the review, we provide relevant background on the biliary ductal system. We then proceed with a general discussion of the factors regulating biliary proliferation performed in the cholestatic animal model of bile duct ligation. Further characterisation of the factors that regulate cholangiocyte proliferation and function will help in elucidating the mechanisms regulating the pathogenesis of biliary tract diseases in humans and in devising new treatment approaches for these devastating diseases.
登录
查看更多内容
影响因子：
6
作者：
Fouassier, Laura;Rosenberg, Peter;Housset, Chantal
通讯作者：
Housset, Chantal
影响因子：
15.9
作者：
Alvaro, D;Alpini, G;Benedetti, A
通讯作者：
Benedetti, A
影响因子：
15.9
作者：
ALVARO, D;CHO, WK;BOYER, JL
通讯作者：
BOYER, JL
影响因子：
29.4
作者：
Alpini, G;Roberts, S;LaRusso, NF
通讯作者：
LaRusso, NF
DOI：
10.1083/jcb.132.6.1199
发表时间：
1996-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bartolazzi A;Nocks A;Aruffo A;Spring F;Stamenkovic I
通讯作者：
Stamenkovic I