Trends in the incidence of syphilis in the middle‐aged and older adults in Japan: A nationwide observational study, 2009-2019
Trends in the incidence of syphilis in the middle‐aged and older adults in Japan: A nationwide observational study, 2009-2019
复制标题
日本中老年人梅毒发病趋势：2009-2019年全国观察性研究
DOI：
10.1111/ggi.14500
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发表时间：
2022
影响因子：
3.3
通讯作者：
Otsuka Fumio
中科院分区：
文献类型：
--
作者：
Takahashi Misa;Hagiya Hideharu;Koyama Toshihiro;Otsuka Fumio
性传播感染仍然是老年医学研究中一个被忽视的领域。然而，在全球老龄化社会中，中年和老年人的性健康是一个新兴的公共问题。高收入国家正面临着年轻一代梅毒病例的死灰复燃，但对老年人群的患病率知之甚少。我们的目的是调查全国趋势的梅毒病例在Japanes.MethodsThis全国性的观察性研究使用公开的数据库（2009 - 2019年），计算粗和年龄调整的发病率梅毒每10万人口的年龄，性别和临床阶段。我们收集了年龄≥ 50岁患者的数据，并进行了联合点回归分析，以估计长期趋势和平均年百分比变化（AAPC）。结果梅毒患者总数从2009年的165例增加到2019年的1280例，增加了约8倍。各年龄组的AAPC粗发病率均显著增加; 50 - 59岁为33.2%，60 - 69岁为23.8%，≥ 70岁为20.9%。AAPC的年龄调整后发病率激增，男性为28.7%，女性为23.1%，2019年男性为4.09，女性为0.71。根据临床分期，观察到原发性（AAPC，男性42.3%，女性41.6%）和二期梅毒（AAPC，男性24.9%，女性24.2%）显着增加。在老龄化的日本社会中，老年人性健康的重要性应该得到重视。Geriatr Gerontol Int 2022; 22：1019 - 1024。
AimSexually transmitted infections remain a neglected area of research in geriatrics. However, in the global aging societies, sexual health among the middle‐aged and older adults is an emerging public concern. High‐income countries are facing a resurgence of syphilis cases among young generations, but little is known about its prevalence in older populations. We aimed to investigate the national trend of syphilis cases in Japan.MethodsThis nationwide observational study used the publicly‐available database (2009–2019) to calculate crude and age‐adjusted incidence rates of syphilis per 100 000 population by age, sex and clinical stage. We collected data from patients aged ≥50 years and performed joinpoint regression analysis to estimate long‐term trends and average annual percentage changes (AAPCs).ResultsThe total number of patients with syphilis increased about 8‐fold from 165 in 2009 to 1280 in 2019. AAPCs of crude incidence rates significantly increased in every age category; 33.2% in 50–59 years, 23.8% in 60–69 years and 20.9% in ≥70 years. Age‐adjusted incidence rates have surged at AAPCs of 28.7% in men and 23.1% in women, reaching 4.09 in men and 0.71 in women in 2019. By clinical stage, marked increases were observed in primary (AAPCs, 42.3% in men and 41.6% in women) and secondary syphilis (AAPCs, 24.9% in men and 24.2% in women).ConclusionsAn up‐toward trend of syphilis among people aged ≥50 years was observed. The importance of sexual health among older people should be highlighted in this aging Japanese society.Geriatr Gerontol Int 2022; 22: 1019–1024.